Impaired ß 2 -adrenergic endothelium-dependent vasodilation in patients previously hospitalized with coronavirus disease 2019.
J Hypertens
; 41(6): 951-957, 2023 06 01.
Article
in English
| MEDLINE | ID: covidwho-2258584
ABSTRACT
AIM:
The pulse wave response to salbutamol (PWRS) - change in augmentation index (AIx) - provides a means to assess endothelial vasodilator function in vivo . Endothelial dysfunction plays a relevant role in the pathogenesis of hypertension and cardiovascular disease and appears to underlie many of the complications of coronavirus disease 2019 (COVID-19). However, to what degree this persists after recovery is unknown.METHODS:
Individuals previously hospitalized with COVID-19, those recovered from mild symptoms and seronegative controls with well known risk factors for endothelial dysfunction were studied. To assess the involvement of nitric oxide-cyclic guanosine monophosphate pathway (NO-cGMP) on PWRS, sildenafil was also administrated in a subsample.RESULTS:
One hundred and one participants (60 men) aged 47.8â±â14.1 (meanâ±âSD) years of whom 33 were previously hospitalized with COVID-19 were recruited. Salbutamol had minimal effect on haemodynamics including blood pressure and heart rate. It reduced AIx in controls ( n â=â34) and those recovered from mild symptoms of COVID-19 ( n â=â34) but produced an increase in AIx in those previously hospitalized mean change [95% confidence interval] -2.85 [-5.52, -0.188] %, -2.32 [-5.17,0.54] %, and 3.03 [0.06, 6.00] % for controls, those recovered from mild symptoms and those previously hospitalized, respectively ( P â=â0.001). In a sub-sample ( n â=â22), sildenafil enhanced PWRS (change in AIx 0.05 [-2.15,2.24] vs. -3.96 [-7.01. -2.18], P â=â0.006) with no significant difference between hospitalized ( n â=â12) and nonhospitalized participants ( n â=â10).CONCLUSIONS:
In patients previously hospitalized with COVID-19, there is long-lasting impairment of endothelial function as measured by the salbutamol-induced stimulation of the NO-cGMP pathway that may contribute to cardiovascular complications.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Hypertension
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Humans
/
Male
Language:
English
Journal:
J Hypertens
Year:
2023
Document Type:
Article
Affiliation country:
HJH.0000000000003420
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