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Gold Nanoparticle-Based Plasmonic Biosensors.
Ferrari, Enrico.
  • Ferrari E; Department of Life Sciences, University of Lincoln, Lincoln LN6 7TS, UK.
Biosensors (Basel) ; 13(3)2023 Mar 22.
Article in English | MEDLINE | ID: covidwho-2259062
ABSTRACT
One of the emerging technologies in molecular diagnostics of the last two decades is the use of gold nanoparticles (AuNPs) for biosensors. AuNPs can be functionalized with various biomolecules, such as nucleic acids or antibodies, to recognize and bind to specific targets. AuNPs present unique optical properties, such as their distinctive plasmonic band, which confers a bright-red color to AuNP solutions, and their extremely high extinction coefficient, which makes AuNPs detectable by the naked eye even at low concentrations. Ingenious molecular mechanisms triggered by the presence of a target analyte can change the colloidal status of AuNPs from dispersed to aggregated, with a subsequent visible change in color of the solution due to the loss of the characteristic plasmonic band. This review describes how the optical properties of AuNPs have been exploited for the design of plasmonic biosensors that only require the simple mixing of reagents combined with a visual readout and focuses on the molecular mechanisms involved. This review illustrates selected examples of AuNP-based plasmonic biosensors and promising approaches for the point-of-care testing of various analytes, spanning from the viral RNA of SARS-CoV-2 to the molecules that give distinctive flavor and color to aged whisky.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biosensing Techniques / Metal Nanoparticles / COVID-19 Limits: Aged / Humans Language: English Year: 2023 Document Type: Article Affiliation country: Bios13030411

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biosensing Techniques / Metal Nanoparticles / COVID-19 Limits: Aged / Humans Language: English Year: 2023 Document Type: Article Affiliation country: Bios13030411