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Immunology of Aging: the Birth of Inflammaging.
Fulop, T; Larbi, A; Pawelec, G; Khalil, A; Cohen, A A; Hirokawa, K; Witkowski, J M; Franceschi, C.
  • Fulop T; Research Center On Aging, Geriatric Division, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, 12th Avenue North, Sherbrooke, QC, 3001J1H 5N4, Canada. Tamas.Fulop@Usherbrooke.ca.
  • Larbi A; Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Biopolis, Singapore, Singapore.
  • Pawelec G; Department of Immunology, University of Tübingen, Tübingen, Germany.
  • Khalil A; Health Sciences North Research Institute, Sudbury, ON, Canada.
  • Cohen AA; Research Center On Aging, Geriatric Division, Department of Medicine, Faculty of Medicine and Health Sciences, University of Sherbrooke, 12th Avenue North, Sherbrooke, QC, 3001J1H 5N4, Canada.
  • Hirokawa K; Groupe de Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada.
  • Witkowski JM; Department of Pathology, Tokyo and Nito-Memory Nakanosogo Hospital, Institute of Health and Life Science, Tokyo Med. Dent. University, Tokyo, Japan.
  • Franceschi C; Department of Pathophysiology, Medical University of Gdansk, Gdansk, Poland.
Clin Rev Allergy Immunol ; 2021 Sep 18.
Article in English | MEDLINE | ID: covidwho-2259748
ABSTRACT
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an evolutionary or rather a revolutionary conceptualization of the immune changes in response to a lifelong stress. This conceptualization permitted to consider the lifelong proinflammatory process as an adaptation which could eventually lead to either beneficial or detrimental consequences. This dichotomy is influenced by both the genetics and the environment. Depending on which way prevails in an individual, the outcome may be healthy longevity or pathological aging burdened with aging-related diseases. The concept of inflammaging has also revealed the complex, systemic nature of aging. Thus, this conceptualization opens the way to consider age-related processes in their complexity, meaning that not only the process but also all counter-processes should be considered. It has also opened the way to add new concepts to the original one, leading to better understanding of the nature of inflammaging and of aging itself. Finally, it showed the way towards potential multimodal interventions involving a holistic approach to optimize the aging process towards a healthy longevity.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S12016-021-08899-6

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S12016-021-08899-6