Associations between brain gene expression perturbations implicated by COVID-19 and psychiatric disorders
Journal of psychiatric research
; 2023.
Article
in English
| EuropePMC | ID: covidwho-2260046
ABSTRACT
Background Currently, there is increasing evidence from clinic, epidemiology, as well as neuroimaging, demonstrating neuropsychiatric abnormalities in COVID-19, however, whether there were associations between brain changes caused by COVID-19 and genetic susceptibility of psychiatric disorders was still unknown. Methods In this study, we performed a meta-analysis to investigate these associations by combing single-cell RNA sequencing datasets of brain tissues of COVID-19 and genome-wide association study summary statistics of psychiatric disorders. Results The analysis demonstrated that among ten psychiatric disorders, gene expression perturbations implicated by COVID-19 in excitatory neurons of choroid plexus were significantly associated with schizophrenia. Conclusions Our analysis might provide insights for the underlying mechanism of the psychiatric consequence of COVID-19.
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Collection:
Databases of international organizations
Database:
EuropePMC
Language:
English
Journal:
Journal of psychiatric research
Year:
2023
Document Type:
Article
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