Acute limb ischemia secondary to vaccine-induced inmune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV-19

Garcia-Boyano, F.; Castro Avila, C. M.; Arguello-Tomas, M.; Moreno Cuervo, A.; Ligero Ramos, J. M.; Pascual-Izquierdo, C.

Garcia-Boyano, F.; Castro Avila, C. M.; Arguello-Tomas, M.; Moreno Cuervo, A.; Ligero Ramos, J. M.; Pascual-Izquierdo, C..

Annals of Vascular Surgery - Brief Reports and Innovations ; 2(3) (no pagination), 2022.

Article in English | EMBASE | ID: covidwho-2260113

ABSTRACT

ABSTRACT

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a syndrome that resembles to heparin-induced thrombocytopenia (HIT). Platelet factor 4 (PF-4) reacts to a vaccine component resulting formation of immune complex that stimulates an autoimmune reaction triggering platelet consumption causing thrombus formation and producing thrombotic events. When suspected is important to confirm for make a correct anticoagulation management to avoid complications related to unfractioned and low weight heparins use. In this report we describe a case of acute limb ischemia secondary to ChAdOx1 nCoV-19 vaccine (Astrazeneca, Cambridge, UK)Copyright © 2022

Keywords

Acute limb ischemia, Covid19, vitt, acute limb ischemia/di [Diagnosis], acute limb ischemia/si [Side Effect], acute limb ischemia/su [Surgery], adult, article, blood sampling, case report, clinical article, clinical feature, cold, computer assisted tomography, coronavirus disease 2019/dt [Drug Therapy], coronavirus disease 2019/pc [Prevention], disease duration, emergency surgery, emergency ward, follow up, foot paralysis, human, intensive care, limb paralysis, male, middle aged, pain, pallor, paresthesia, postoperative period, priority journal, thrombectomy, vaccine-induced immune thrombotic thrombocytopenia/di [Diagnosis], vaccine-induced immune thrombotic thrombocytopenia/dt [Drug Therapy], vaccine-induced immune thrombotic thrombocytopenia/si [Side Effect], argatroban/dt [Drug Therapy], dabigatran/dt [Drug Therapy], dabigatran/po [Oral Drug Administration], immunoglobulin/dt [Drug Therapy], immunoglobulin/iv [Intravenous Drug Administration], methylprednisolone/dt [Drug Therapy], methylprednisolone/iv [Intravenous Drug Administration], vaxzevria/ae [Adverse Drug Reaction], vaxzevria/dt [Drug Therapy]

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Full text: Available Collection: Databases of international organizations Database: EMBASE Topics: Vaccines Language: English Journal: Annals of Vascular Surgery - Brief Reports and Innovations Year: 2022 Document Type: Article

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