Trends and cyclic variation in the incidence of childhood type 1 diabetes in two Italian regions over 33 years and during the COVID-19 pandemic.
Diabetes Obes Metab
; 25(6): 1698-1703, 2023 06.
Article
in English
| MEDLINE | ID: covidwho-2260455
ABSTRACT
AIM:
There is conflicting evidence about the impact of the COVID-19 pandemic on the incidence of type 1 diabetes. Here, we analysed long-term trends in the incidence of type 1 diabetes in Italian children and adolescents from 1989 to 2019 and compared the incidence observed during the COVID-19 pandemic with that estimated from long-term data. MATERIALS ANDMETHODS:
This was a population-based incidence study using longitudinal data from two diabetes registries in mainland Italy. Trends in the incidence of type 1 diabetes from 1 January 1989 to 31 December 2019 were estimated using Poisson and segmented regression models.RESULTS:
There was a significant increasing trend in the incidence of type 1 diabetes of 3.6% per year [95% confidence interval (CI) 2.4-4.8] between 1989 and 2003, a breakpoint in 2003, and then a constant incidence until 2019 (0.5%, 95% CI -1.3 to 2.4). There was a significant 4-year cycle in incidence over the entire study period. The rate observed in 2021 (26.7, 95% CI 23.0-30.9) was significantly higher than expected (19.5, 95% CI 17.6-21.4; p = .010).CONCLUSION:
Long-term incidence analysis showed an unexpected increase in new cases of type 1 diabetes in 2021. The incidence of type 1 diabetes now needs continuous monitoring using population registries to understand better the impact of COVID-19 on new-onset type 1 diabetes in children.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 1
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Child
/
Humans
Country/Region as subject:
Europa
Language:
English
Journal:
Diabetes Obes Metab
Journal subject:
Endocrinology
/
Metabolism
Year:
2023
Document Type:
Article
Affiliation country:
Dom.15024
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