Emerging Paradigms in Type 2 Immunity.
Annu Rev Immunol
; 40: 443-467, 2022 04 26.
Article
in English
| MEDLINE | ID: covidwho-2262002
ABSTRACT
A principal purpose of type 2 immunity was thought to be defense against large parasites, but it also functions in the restoration of homeostasis, such as toxin clearance following snake bites. In other cases, like allergy, the type 2 T helper (Th2) cytokines and cells present in the environment are detrimental and cause diseases. In recent years, the recognition of cell heterogeneity within Th2-associated cell populations has revealed specific functions of cells with a particular phenotype or gene signature. In addition, here we discuss the recent data regarding heterogeneity of type 2 immunity-related cells, as well as their newly identified role in a variety of processes ranging from involvement in respiratory viral infections [especially in the context of the recent COVID-19 (coronavirus disease 2019) pandemic] to control of cancer development or of metabolic homeostasis.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Hypersensitivity
Type of study:
Observational study
Limits:
Animals
/
Humans
Language:
English
Journal:
Annu Rev Immunol
Year:
2022
Document Type:
Article
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