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Heart transplantation for pediatric foreign nationals in the United States.
Harano, Takashi; Sheth, Megha; Sasaki, Kazunari; Yu, Jeremy; Wightman, Sean C; Atay, Scott M; Sainathan, Sandeep; Kim, Anthony W.
  • Harano T; Division of Thoracic Surgery, Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
  • Sheth M; Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
  • Sasaki K; Division of Abdominal Transplant, Department of Surgery, Stanford University, Palo Alto, California, USA.
  • Yu J; Department of Psychiatry and Behavioral Sciences & SC CTSI Biostatistics, Epidemiology, and Research Design, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
  • Wightman SC; Division of Thoracic Surgery, Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
  • Atay SM; Division of Thoracic Surgery, Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
  • Sainathan S; Division of Cardiothoracic Surgery, Department of Surgery, University of Miami, Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.
  • Kim AW; Division of Thoracic Surgery, Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Clin Transplant ; 37(2): e14900, 2023 02.
Article in English | MEDLINE | ID: covidwho-2262192
ABSTRACT

BACKGROUND:

This study aimed to clarify survival outcomes, waitlist mortality, and waitlist days of heart transplantation of pediatric foreign nationals compared to pediatric United States (US) citizens.

METHODS:

We retrieved data from March 2012 to June 2021 in the United Network Organ Sharing (UNOS) registry.

RESULTS:

Of 5857 pediatric patients newly waitlisted, 133 (2.27%) patients were non-US citizen/non-US residents (non-citizen non-resident [NCNR]). Patients with congenital heart disease were higher in the US citizen group than in the NCNR group (51.9% vs. 22.6%, p < .001); 76.7% of patients in the NCNR group (102/133) had cardiomyopathy. Of the 133 NCNRs, 111 patients (83.5%) underwent heart transplantation, which was significantly higher than that in the US citizen group (68.6%, p < .001). The median waitlist time was 71 days (IQR, 22-172 days) in the NCNR group and 74 days (29-184 days) in the US citizen group (p = .48). Survival after heart transplant was significantly better in the NCNR group than in the US citizen group (n = 3982; logrank test p = .015).

CONCLUSIONS:

Heart transplantation for pediatric foreign nationals was mostly indicated for cardiomyopathy, and their transplant rate was significantly higher than that in the US citizen group, with better survival outcomes. The better survival outcomes in the NCNR group compared to the US citizen group can likely be attributed to the differing diagnoses for which transplantation was performed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heart Transplantation / Transplants / Heart Defects, Congenital Type of study: Prognostic study Limits: Child / Humans Country/Region as subject: North America Language: English Journal: Clin Transplant Journal subject: Transplantation Year: 2023 Document Type: Article Affiliation country: Ctr.14900

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heart Transplantation / Transplants / Heart Defects, Congenital Type of study: Prognostic study Limits: Child / Humans Country/Region as subject: North America Language: English Journal: Clin Transplant Journal subject: Transplantation Year: 2023 Document Type: Article Affiliation country: Ctr.14900