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Immunopathogenesis and immunomodulatory therapy for myocarditis.
He, Wu; Zhou, Ling; Xu, Ke; Li, Huihui; Wang, James Jiqi; Chen, Chen; Wang, DaoWen.
  • He W; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Zhou L; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, 430030, China.
  • Xu K; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Li H; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, 430030, China.
  • Wang JJ; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • Chen C; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, 430030, China.
  • Wang D; Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Sci China Life Sci ; 2023 Mar 29.
Article in English | MEDLINE | ID: covidwho-2262533
ABSTRACT
Myocarditis is an inflammatory cardiac disease characterized by the destruction of myocardial cells, infiltration of interstitial inflammatory cells, and fibrosis, and is becoming a major public health concern. The aetiology of myocarditis continues to broaden as new pathogens and drugs emerge. The relationship between immune checkpoint inhibitors, severe acute respiratory syndrome coronavirus 2, vaccines against coronavirus disease-2019, and myocarditis has attracted increased attention. Immunopathological processes play an important role in the different phases of myocarditis, affecting disease occurrence, development, and prognosis. Excessive immune activation can induce severe myocardial injury and lead to fulminant myocarditis, whereas chronic inflammation can lead to cardiac remodelling and inflammatory dilated cardiomyopathy. The use of immunosuppressive treatments, particularly cytotoxic agents, for myocarditis, remains controversial. While reasonable and effective immunomodulatory therapy is the general trend. This review focuses on the current understanding of the aetiology and immunopathogenesis of myocarditis and offers new perspectives on immunomodulatory therapies.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Prognostic study Topics: Vaccines Language: English Journal subject: Biology / Science Year: 2023 Document Type: Article Affiliation country: S11427-022-2273-3

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Prognostic study Topics: Vaccines Language: English Journal subject: Biology / Science Year: 2023 Document Type: Article Affiliation country: S11427-022-2273-3