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Outcome of COVID-19 Infection in Cancer Patients in Pune.
Hingmire, Sachin; Wategaonkar, Ravikumar; Hegde, Sujai; Mekha, Mangesh; Kulkarni, Rahul; Rajbhoj, Ashwin; Deshmukh, Chetan; Kulkarni, Padmaj; Patil, Tushar; Kanitkar, Gajanan; Wanjarkhedkar, Pankaj; Mane, Anupama; Bokil, Kamlesh; Parasnis, Amit; Gawande, Jayant; Bhatia, Jatin; Khaladkar, Bhagyashree; Sirsath, Nagesh; Melinkeri, Sameer; Kashyapi, Bhalchandra; Agrawal, Rakesh Kumar; Prabhakaran, Anushree; Desai, Isha; Kelkar, Dhananjay.
  • Hingmire S; Department of Oncology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
  • Wategaonkar R; Department of Oncology, Aditya Birla Memorial Hospital, Pune, Maharashtra, India.
  • Hegde S; Department of Oncology, Ruby Hall Clinic, Pune, Maharashtra, India.
  • Mekha M; Department of Oncology, Jehangir Hospital, Pune, Maharashtra, India.
  • Kulkarni R; Department of Oncology, Sahyadri Superspecialty Hospital, Pune, Maharashtra, India.
  • Rajbhoj A; Department of Oncology, KEM Hospital, Pune, Maharashtra, India.
  • Deshmukh C; Department of Oncology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
  • Kulkarni P; Department of Oncology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
  • Patil T; Department of Oncology, Sahyadri Superspecialty Hospital, Pune, Maharashtra, India.
  • Kanitkar G; Department of Oncology, Ruby Hall Clinic, Pune, Maharashtra, India.
  • Wanjarkhedkar P; Department of Oncology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
  • Mane A; Department of Oncology, Jehangir Hospital, Pune, Maharashtra, India.
  • Bokil K; Dwidal Nursing Home, Pune, Maharashtra, India.
  • Parasnis A; Department of Oncology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
  • Gawande J; Department of Oncology, Aditya Birla Memorial Hospital, Pune, Maharashtra, India.
  • Bhatia J; Department of Oncology, Jupiter Hospital, Pune, Maharashtra, India.
  • Khaladkar B; Department of Oncology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
  • Sirsath N; Department of Oncology, Inlaks & Budhrani Hospital, Pune, Maharashtra, India.
  • Melinkeri S; Department of Oncology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
  • Kashyapi B; Department of Oncology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
  • Agrawal RK; Department of Oncology, Aditya Birla Memorial Hospital, Pune, Maharashtra, India.
  • Prabhakaran A; Department of Oncology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
  • Desai I; Department of Medicine, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
  • Kelkar D; Department of Oncology, Deenanath Mangeshkar Hospital & Research Center, Pune, Maharashtra, India.
South Asian J Cancer ; 10(1): 23-27, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-2262908
ABSTRACT
Introduction We document our data on the course of the coronavirus disease 2019 (COVID-19) infection in cancer patients in an attempt to help optimize their management in India and globally. Material and Methods Between February 2020 and January 2021, participating oncologists from Pune (members of the Oncology Group of Pune) documented effect of COVID-19 infection in their cancer patients. Binomial logistic regression analysis as well as correlation analysis was done using Pearson Chi-square test to determine significance of clinical factors. Results A total of 29 oncologists from 20 hospitals contributed their data involving 147 cancer patients who developed COVID-19 infections. COVID-19 infection resulted in higher deaths (likelihood ratio of 4.4) amongst patients with hematological malignancies (12/44 = 27.2%) as compared with those with solid tumors (13/90 = 14.4%, p = 0.030). Patients with uncontrolled or progressive cancer (11/34 = 32.4%) when they got infected with COVID-19 had higher mortality as compared with patients whose cancer was under control (14/113 = 12.4%; p = 0.020). Complication of thromboembolic episodes (seen in eight patients; 5.4% cases) was associated with higher risk (25.6 times) of death (five-eighths; 62.5%) as compared with those who did not develop it (20/139;14.4%; p <0.001). Discussion Patients with cancer should be advised to take strict precautions to reduce the risk of being infected with COVID-19. They should also be given priority for COVID-19 vaccination. If infected with COVID-19, patients with hematological malignancy and uncontrolled cancer are at higher risk of morbidity and mortality. When they are being treated (OPD or inpatient basis), additional precautions are necessary to ensure their exposure to potential COVID-19 virus is minimized. If they get infected with COVID-19, they should be given aggressive treatment to prevent complications, especially thromboembolic episodes. If they develop any thromboembolic complication, their risk of dying are significantly higher, and management should be modified accordingly.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Vaccines Language: English Journal: South Asian J Cancer Year: 2021 Document Type: Article Affiliation country: S-0041-1731910

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Vaccines Language: English Journal: South Asian J Cancer Year: 2021 Document Type: Article Affiliation country: S-0041-1731910