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Antibiotic use for respiratory tract infections among older adults living in long-term care facilities: a systematic review and meta-analysis.
Huang, Y; Wei, W I; Correia, D F; Ma, B H M; Tang, A; Yeoh, E K; Wong, S Y S; Ip, M; Kwok, K O.
  • Huang Y; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Wei WI; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Correia DF; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
  • Ma BHM; Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong Special Administrative Region, China.
  • Tang A; College of Computing and Informatics, Sungkyunkwan University, Seoul, Republic of Korea.
  • Yeoh EK; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Wong SYS; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Ip M; Department of Microbiology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Kwok KO; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Shenzhen Research Institute of th
J Hosp Infect ; 131: 107-121, 2022 Oct 04.
Article in English | MEDLINE | ID: covidwho-2263492
ABSTRACT

BACKGROUND:

Antibiotics are commonly prescribed for respiratory tract infections (RTIs) among older adults in long-term care facilities (LTCFs), and this contributes to the emergence of antimicrobial resistance. The objective of this study was to determine the antibiotic prescribing rate for RTIs among LTCF residents, and to analyse the antibiotic consumption patterns with the AwaRe monitoring tool, developed by the World Health Organization.

METHODS:

MEDLINE, EMBASE and CINAHL were searched from inception to March 2022. Original articles reporting antibiotic use for RTIs in LTCFs were included in this review. Study quality was assessed using the Joanna Briggs Institute's Critical Appraisal Checklist for Prevalence Data. A random-effects meta-analysis was employed to calculate the pooled estimates. Subgroup analysis was conducted by type of RTI, country, and study start year.

RESULTS:

In total, 47 articles consisting of 50 studies were included. The antibiotic prescribing rate ranged from 21.5% to 100% (pooled estimate 69.8%, 95% confidence interval 55.2-82.6%). The antibiotic prescribing rate for lower respiratory tract infections (LRTIs) was higher than the rates for viral and general RTIs. Compared with Italy, France and the USA, the Netherlands had lower antibiotic use for LRTIs. A proportion of viral RTIs were treated with antibiotics, and all the antibiotics were from the Watch group. Use of antibiotics in the Access group was higher in the Netherlands, Norway, Switzerland and Slovenia compared with the USA and Australia.

CONCLUSION:

The antibiotic prescribing rate for RTIs in LTCFs was high, and AWaRe antibiotic use patterns varied by type of RTI and country. Improving antibiotic use may require coordination efforts.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Language: English Journal: J Hosp Infect Year: 2022 Document Type: Article Affiliation country: J.jhin.2022.09.016

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Language: English Journal: J Hosp Infect Year: 2022 Document Type: Article Affiliation country: J.jhin.2022.09.016