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Saliva - a new opportunity for fluid biopsy.
Huang, Zhijie; Yang, Xiaoxia; Huang, Yisheng; Tang, Zhengming; Chen, Yuanxin; Liu, Hongyu; Huang, Mingshu; Qing, Ling; Li, Li; Wang, Qin; Jie, Zhuye; Jin, Xin; Jia, Bo.
  • Huang Z; Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, P.R. China.
  • Yang X; Department of Endodontics, Stomatological Hospital, Southern Medical University, Guangzhou, P.R. China.
  • Huang Y; Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, P.R. China.
  • Tang Z; Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, P.R. China.
  • Chen Y; Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, P.R. China.
  • Liu H; Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, P.R. China.
  • Huang M; Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, P.R. China.
  • Qing L; Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, P.R. China.
  • Li L; Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, P.R. China.
  • Wang Q; Department of Oral Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, P.R. China.
  • Jie Z; BGI Genomics, BGI-Shenzhen, Shenzhen, P.R. China.
  • Jin X; Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, P.R. China.
  • Jia B; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Clin Chem Lab Med ; 61(1): 4-32, 2023 01 27.
Article in English | MEDLINE | ID: covidwho-2263496
ABSTRACT
Saliva is a complex biological fluid with a variety of biomolecules, such as DNA, RNA, proteins, metabolites and microbiota, which can be used for the screening and diagnosis of many diseases. In addition, saliva has the characteristics of simple collection, non-invasive and convenient storage, which gives it the potential to replace blood as a new main body of fluid biopsy, and it is an excellent biological diagnostic fluid. This review integrates recent studies and summarizes the research contents of salivaomics and the research progress of saliva in early diagnosis of oral and systemic diseases. This review aims to explore the value and prospect of saliva diagnosis in clinical application.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Microbiota Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Clin Chem Lab Med Journal subject: Chemistry, Clinical / Laboratory Techniques and procedures Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Microbiota Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Clin Chem Lab Med Journal subject: Chemistry, Clinical / Laboratory Techniques and procedures Year: 2023 Document Type: Article