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Proof-of-concept: SCENTinel 1.1 rapidly discriminates COVID-19-related olfactory disorders.
Hunter, Stephanie R; Hannum, Mackenzie E; Pellegrino, Robert; O'Leary, Maureen A; Rawson, Nancy E; Reed, Danielle R; Dalton, Pamela H; Parma, Valentina.
  • Hunter SR; Monell Chemical Senses Center, Philadelphia, PA, United States.
  • Hannum ME; Monell Chemical Senses Center, Philadelphia, PA, United States.
  • Pellegrino R; Monell Chemical Senses Center, Philadelphia, PA, United States.
  • O'Leary MA; Monell Chemical Senses Center, Philadelphia, PA, United States.
  • Rawson NE; Monell Chemical Senses Center, Philadelphia, PA, United States.
  • Reed DR; Monell Chemical Senses Center, Philadelphia, PA, United States.
  • Dalton PH; Monell Chemical Senses Center, Philadelphia, PA, United States.
  • Parma V; Monell Chemical Senses Center, Philadelphia, PA, United States.
Chem Senses ; 482023 01 01.
Article in English | MEDLINE | ID: covidwho-2263621
ABSTRACT
It is estimated that 20%-67% of those with COVID-19 develop olfactory disorders, depending on the SARS-CoV-2 variant. However, there is an absence of quick, population-wide olfactory tests to screen for olfactory disorders. The purpose of this study was to provide a proof-of-concept that SCENTinel 1.1, a rapid, inexpensive, population-wide olfactory test, can discriminate between anosmia (total smell loss), hyposmia (reduced sense of smell), parosmia (distorted odor perception), and phantosmia (odor sensation without a source). Participants were mailed a SCENTinel 1.1 test, which measures odor detection, intensity, identification, and pleasantness, using one of 4 possible odors. Those who completed the test (N = 287) were divided into groups based on their self-reported olfactory function quantitative olfactory disorder only (anosmia or hyposmia, N = 135), qualitative olfactory disorder only (parosmia and/or phantosmia; N = 86), and normosmia (normal sense of smell; N = 66). SCENTinel 1.1 accurately discriminates quantitative olfactory disorders, qualitative olfactory disorders, and normosmia groups. When olfactory disorders were assessed individually, SCENTinel 1.1 discriminates between hyposmia, parosmia, and anosmia. Participants with parosmia rated common odors less pleasant than those without parosmia. We provide proof-of-concept that SCENTinel 1.1, a rapid smell test, can discriminate quantitative and qualitative olfactory disorders, and is the only direct test to rapidly discriminate parosmia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Olfaction Disorders Type of study: Diagnostic study / Experimental Studies / Qualitative research / Randomized controlled trials Topics: Variants Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Chemse

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Olfaction Disorders Type of study: Diagnostic study / Experimental Studies / Qualitative research / Randomized controlled trials Topics: Variants Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Chemse