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Neutrophilic dermatosis with necrobiotic changes as an unusual manifestation after the first shot of a COVID-19 mRNA vaccine together with a high fever and liver injury
Journal of Cutaneous Immunology and Allergy ; 6(2):49-54, 2023.
Article in English | ProQuest Central | ID: covidwho-2263847
ABSTRACT
Coronavirus disease 19 (COVID-19) mRNA vaccines sometimes cause various skin rashes. We report an unusual case of erythema nodosum-like nodules with vesicular and pustular papules, which arose after the first shot of a COVID-19 mRNA vaccine. A skin biopsy showed marked neutrophilic infiltration with necrobiotic changes throughout the dermis and subcutis. Immunohistochemically, CD8+ cells were much more common than CD4+ cells in the dense neutrophilic infiltrates. Many CD68+ macrophages were present around the CD8+ cells. No cases of neutrophilic dermatosis with necrobiotic changes have been reported. Thus, our findings should be added to the cutaneous adverse effects of the vaccines.
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Full text: Available Collection: Databases of international organizations Database: ProQuest Central Topics: Vaccines Language: English Journal: Journal of Cutaneous Immunology and Allergy Year: 2023 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: ProQuest Central Topics: Vaccines Language: English Journal: Journal of Cutaneous Immunology and Allergy Year: 2023 Document Type: Article