Comparison of the Effects of Continuous Renal Replacement Therapy and Hemodialysis on Complications, Vital Signs, and Laboratory Parameters in Patients with COVID-19

ABSTRACT

Introduction: Evidence shows that continuous renal replacement therapy (CRRT) and hemodialysis may be effective in the treatment of Coronavirus disease-2019 (COVID-19). This study aimed to compare the effects of CRRT and hemodialysis on complications, vital signs, and laboratory parameters in patients with COVID-19. Material(s) and Method(s) This cross-sectional study was performed on 113 patients with COVID-19 who underwent hemoperfusion in Kosar Hospital of Semnan city (Iran) between 2020 and 2021. The patients were divided into two groups, the CRRT hemoperfusion group (n=49) and the hemodialysis group (n=64). A checklist was used for collecting data, which included demographic variables, history of underlying diseases, vital signs, laboratory parameters, complications, and various outcomes, which were extracted through interviews with patients or companions and in medical records. IBM Statistical Package for the Social Sciences Statistics for Windows version 26 was used for data analysis. Result(s) The time from hemoperfusion to hospital discharge (3.84+/-4.51 vs. 5.92+/-4.16 day), duration of intubation (0.33+/-0.94 vs. 1.84+/-3.42), death after hemoperfusion (64.06 vs. 26.5%), situational instability (21.9 vs. 8.2%), and death during hemoperfusion (14.1 vs. 0%) were significantly lower in the CRRT group than in the hemodialysis group (p<0.05). In the repeated-measures analysis of variance (ANOVA) test, the two groups demonstrated a statistically significant difference in lactate dehydrogenase, alkaline phosphatase, white blood cell count, and C-reactive protein at different time points;thus, the mean of these variables was significantly lower after hemoperfusion in the CRRT group than in the hemodialysis group (p<0.05). Conclusion(s) Continuous renal replacement therapy hemoperfusion can be effective in the recovery process of patients with COVID-19 because the length of hospital stay, intubation period, situational instability, and mortality during and after hemoperfusion are less than those of hemodialysis. © Copyright 2022 by the Infectious Diseases and Clinical Microbiology Specialty Society of Turkey Mediterranean Journal of Infection, Microbes and Antimicrobials published by Galenos Yayinevi.