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A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection.
Jamison, David A; Anand Narayanan, S; Trovão, Nídia S; Guarnieri, Joseph W; Topper, Michael J; Moraes-Vieira, Pedro M; Zaksas, Viktorija; Singh, Keshav K; Wurtele, Eve Syrkin; Beheshti, Afshin.
  • Jamison DA; COVID-19 International Research Team, Medford, MA, USA.
  • Anand Narayanan S; COVID-19 International Research Team, Medford, MA, USA. anarayan09@gmail.com.
  • Trovão NS; Department of Nutrition & Integrative Physiology, Florida State University, Tallahassee, FL, USA. anarayan09@gmail.com.
  • Guarnieri JW; COVID-19 International Research Team, Medford, MA, USA.
  • Topper MJ; Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
  • Moraes-Vieira PM; COVID-19 International Research Team, Medford, MA, USA.
  • Zaksas V; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Singh KK; COVID-19 International Research Team, Medford, MA, USA.
  • Wurtele ES; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
  • Beheshti A; COVID-19 International Research Team, Medford, MA, USA.
Eur J Hum Genet ; 30(8): 889-898, 2022 08.
Article in English | MEDLINE | ID: covidwho-2264387
ABSTRACT
COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus' mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Eur J Hum Genet Journal subject: Genetics, Medical Year: 2022 Document Type: Article Affiliation country: S41431-022-01108-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Eur J Hum Genet Journal subject: Genetics, Medical Year: 2022 Document Type: Article Affiliation country: S41431-022-01108-8