Thromboelastography Parameters do not Discriminate for Thrombotic Events in Hospitalized Patients With COVID-19.
J Intensive Care Med
; : 8850666221142265, 2022 Nov 29.
Article
in English
| MEDLINE | ID: covidwho-2265653
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) is associated with a prothrombotic state; leading to multiple sequelae. We sought to detect whether thromboelastography (TEG) parameters would be able to detect thromboembolic events in patients hospitalized with COVID-19.METHODS:
We performed a retrospective multicenter case-control study of the Collaborative Research to Understand the Sequelae of Harm in COVID (CRUSH COVID) registry of 8 tertiary care level hospitals in the United States (US). This registry contains adult patients with COVID-19 hospitalized between March 2020 and September 2020.RESULTS:
A total of 277 hospitalized COVID-19 patients were analyzed to determine whether conventional coagulation TEG parameters were associated with venous thromboembolic (VTE) and thrombotic events during hospitalization. A clotting index (CI) >3 was present in 45.8% of the population, consistent with a hypercoagulable state. Eighty-three percent of the patients had clot lysis at 30 min (LY30) = 0, consistent with fibrinolysis shutdown, with a median of 0.1%. We did not find TEG parameters (LY30 area under the receiver operating characteristic [ROC] curve [AUC] = 0.55, 95% CI 0.44-0.65, P value = .32; alpha angle [α] AUC = 0.58, 95% CI 0.47-0.69, P value = .17; K time AUC = 0.58, 95% CI 0.46-0.69, P value = .67; maximum amplitude (MA) AUC = 0.54, 95% CI 0.44-0.64, P value = .47; reaction time [R time] AUC = 0.53, 95% CI 0.42-0.65, P value = .70) to be a good discriminator for VTE. We also did not find TEG parameters (LY30 AUC = 0.51, 95% CI 0.42-0.60, P value = .84; R time AUC = 0.57, 95%CI 0.48-0.67, P value .07; α AUC = 0.59, 95%CI 0.51-0.68, P value = .02; K time AUC = 0.62, 95% CI 0.53-0.70, P value = .07; MA AUC = 0.65, 95% CI 0.57-0.74, P value < .01) to be a good discriminator for thrombotic events.CONCLUSIONS:
In this retrospective multicenter cohort study, TEG in COVID-19 hospitalized patients may indicate a hypercoagulable state, however, its use in detecting VTE or thrombotic events is limited in this population.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Language:
English
Journal:
J Intensive Care Med
Journal subject:
Critical Care
Year:
2022
Document Type:
Article
Affiliation country:
08850666221142265
Similar
MEDLINE
...
LILACS
LIS