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Polycystic Ovary Syndrome and COVID-19.
Endokrinologya ; 27(1):30-36, 2022.
Article in Bulgarian | EMBASE | ID: covidwho-2266915
ABSTRACT
Polycystic ovary syndrome (PCOS) is generally characterized by hyperandrogenism, obesity, chronic low-grade inflammation, abnormalities in carbohydrate and lipid metabolism, vit. D deficiency and gut microbiota dysbiosis. Each of the aforementioned disturbances might be considered as a risk factor for increased SARS-CoV-2 susceptibility and more severe COVID-19 infection in women with PCOS. Hyperandrogenism is thought to play an essential role for determining the grade of susceptibility as well as the risk of severe COVID-19 infection in PCOS. It could be explained by the expression of a specific cellular co-receptor - transmembrane serine protease-2 (TMPRSS2), the process of androgen-dependent immune modulation and that of the stimulated renin-angiotensin system (RAS). Android obesity, commonly seen in PCOS, represents a condition of chronic low-grade inflammation that leads to the development of immune dysfunction and increased sensitivity to SARS-CoV-2 among the carriers of this syndrome. In addition, vit. D deficiency and gut dysbiosis have been described as other potential pathophysiological factors contributing to an increased risk for severe COVID-19 in women with PCOS.Copyright © 2022 Medical Information Center. All rights reserved.
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Collection: Databases of international organizations Database: EMBASE Language: Bulgarian Journal: Endokrinologya Year: 2022 Document Type: Article

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Collection: Databases of international organizations Database: EMBASE Language: Bulgarian Journal: Endokrinologya Year: 2022 Document Type: Article