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Predictors of Mortality among Patients Hospitalized with COVID-19 during the First Wave in India: A Multisite Case-Control Study.
Krishnan, Anand; Kumar, Rakesh; Amarchand, Ritvik; Mohan, Anant; Kant, Ravi; Agarwal, Ankit; Kulshreshtha, Poorvi; Panda, Prasan Kumar; Bhadoria, Ajeet Singh; Agarwal, Neeraj; Biswas, Bijit; Nair, Rathish; Wig, Naveet; Malhotra, Rajesh; Bhatnagar, Sushma; Aggarwal, Richa; Soni, Kapil Dev; Madan, Nirupam; Trikha, Anjan; Tiwari, Pawan; Singh, Angel Rajan; Wyawahare, Mukta; Gunasekaran, Venugopalan; Sekar, Dineshbabu; Misra, Sanjeev; Bhardwaj, Pankaj; Goel, Akhil Dhanesh; Dutt, Naveen; Kumar, Deepak; Nagarkar, Nitin M; Galhotra, Abhiruchi; Jindal, Atul; Raj, Utsav; Behera, Ajoy; Siddiqui, Sabbah; Kokane, Arun; Joshi, Rajnish; Pakhare, Abhijit; Farooque, Farhan; Pawan, Sai; Deshmukh, Pradeep; Solanki, Ranjan; Rathod, Bharatsing; Dutta, Vibha; Mohapatra, Prasanta Raghab; Panigrahi, Manoj Kumar; Barik, Sadananda; Guleria, Randeep.
  • Krishnan A; Centre for Community Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
  • Kumar R; Centre for Community Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
  • Amarchand R; Centre for Community Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
  • Mohan A; Department of Pulmonary, Critical Care and Sleep Medicine, AIIMS, New Delhi, India.
  • Kant R; AIIMS, Rishikesh, India.
  • Agarwal A; Department of Anaesthesia, AIIMS, Rishikesh, India.
  • Kulshreshtha P; Department of Physiology, AIIMS, Rishikesh, India.
  • Panda PK; Department of Medicine, AIIMS, Rishikesh, India.
  • Bhadoria AS; Department of Community & Family Medicine, AIIMS, Rishikesh, India.
  • Agarwal N; Department of Community & Family Medicine, AIIMS, Patna, India.
  • Biswas B; Department of Community & Family Medicine, AIIMS, Patna, India.
  • Nair R; College of Nursing, AIIMS, Patna, India.
  • Wig N; Department of Medicine, AIIMS, New Delhi, India.
  • Malhotra R; Jai Prakash Narayan Apex Trauma Center, AIIMS, New Delhi, India.
  • Bhatnagar S; Department of Onco-Anaesthesia, BRAIRCH, AIIMS, New Delhi, India.
  • Aggarwal R; Department of Anaesthesia and Critical Care, Jai Prakash Narayan Apex Trauma Center, AIIMS, New Delhi, India.
  • Soni KD; Department of Anaesthesia and Critical Care, Jai Prakash Narayan Apex Trauma Center, AIIMS, New Delhi, India.
  • Madan N; Department of Hospital Administration, AIIMS, New Delhi, India.
  • Trikha A; Department of Anaesthesiology, Pain Medicine and Critical Care, AIIMS, New Delhi, India.
  • Tiwari P; Department of Pulmonary, Critical Care and Sleep Medicine, AIIMS, New Delhi, India.
  • Singh AR; Department of Hospital Administration, AIIMS, New Delhi, India.
  • Wyawahare M; Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), India.
  • Gunasekaran V; Department of Geriatric Medicine, JIPMER, India.
  • Sekar D; Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), India.
  • Misra S; AIIMS, Jodhpur, India.
  • Bhardwaj P; Department of Community & Family Medicine, AIIMS, Jodhpur, India.
  • Goel AD; Department of Community & Family Medicine, AIIMS, Jodhpur, India.
  • Dutt N; Department of Pulmonary Medicine, AIIMS, Jodhpur, India.
  • Kumar D; Department of Medicine, AIIMS, Jodhpur, India.
  • Nagarkar NM; AIIMS, Raipur, India.
  • Galhotra A; Department of Community & Family Medicine, AIIMS, Raipur, India.
  • Jindal A; Department of Paediatrics, AIIMS, Raipur, India.
  • Raj U; National Tuberculosis Elimination Program, AIIMS, Raipur, India.
  • Behera A; Department of Pulmonary Medicine, AIIMS, Raipur, India.
  • Siddiqui S; Department of Medicine, AIIMS, Raipur, India.
  • Kokane A; Department of Community & Family Medicine, AIIMS, Bhopal, India.
  • Joshi R; Department of Medicine, AIIMS, Bhopal, India.
  • Pakhare A; Department of Community & Family Medicine, AIIMS, Bhopal, India.
  • Farooque F; Department of Community & Family Medicine, AIIMS, Bhopal, India.
  • Pawan S; Department of Medicine, AIIMS, Bhopal, India.
  • Deshmukh P; Department of Community & Family Medicine, AIIMS, Nagpur, India.
  • Solanki R; Department of Community & Family Medicine, AIIMS, Nagpur, India.
  • Rathod B; Department of Medicine, AIIMS, Nagpur, India.
  • Dutta V; AIIMS, Nagpur, India.
  • Mohapatra PR; Department of Pulmonary Medicine & Critical Care, AIIMS, Bhubaneswar, India.
  • Panigrahi MK; Department of Pulmonary Medicine & Critical Care, AIIMS, Bhubaneswar, India.
  • Barik S; Department of Trauma & Emergency Medicine, AIIMS, Bhubaneswar, India.
  • Guleria R; AIIMS, New Delhi, India.
Am J Trop Med Hyg ; 108(4): 727-733, 2023 04 05.
Article in English | MEDLINE | ID: covidwho-2267264
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 disease (COVID-19) has caused more than 6 million deaths globally. Understanding predictors of mortality will help in prioritizing patient care and preventive approaches. This was a multicentric, unmatched, hospital-based case-control study conducted in nine teaching hospitals in India. Cases were microbiologically confirmed COVID-19 patients who died in the hospital during the period of study and controls were microbiologically confirmed COVID-19 patients who were discharged from the same hospital after recovery. Cases were recruited sequentially from March 2020 until December-March 2021. All information regarding cases and controls was extracted retrospectively from the medical records of patients by trained physicians. Univariable and multivariable logistic regression was done to assess the association between various predictor variables and deaths due to COVID-19. A total of 2,431 patients (1,137 cases and 1,294 controls) were included in the study. The mean age of patients was 52.8 years (SD 16.5 years), and 32.1% were females. Breathlessness was the most common symptom at the time of admission (53.2%). Increasing age (adjusted odds ratio [aOR] 46-59 years, 3.4 [95% CI 1.5-7.7]; 60-74 years, 4.1 [95% CI 1.7-9.5]; and ≥ 75 years, 11.0 [95% CI 4.0-30.6]); preexisting diabetes mellitus (aOR 1.9 [95% CI 1.2-2.9]); malignancy (aOR 3.1 [95% CI 1.3-7.8]); pulmonary tuberculosis (aOR 3.3 [95% CI 1.2-8.8]); breathlessness at the time of admission (aOR 2.2 [95% CI 1.4-3.5]); high quick Sequential Organ Failure Assessment score at the time of admission (aOR 5.6 [95% CI 2.7-11.4]); and oxygen saturation < 94% at the time of admission (aOR 2.5 [95% CI 1.6-3.9]) were associated with mortality due to COVID-19. These results can be used to prioritize patients who are at increased risk of death and to rationalize therapy to reduce mortality due to COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Language: English Journal: Am J Trop Med Hyg Year: 2023 Document Type: Article Affiliation country: Ajtmh.22-0705

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Language: English Journal: Am J Trop Med Hyg Year: 2023 Document Type: Article Affiliation country: Ajtmh.22-0705