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An unusually fulminant case of encephalomyelitis in an 80 year old
Neuroimmunology Reports ; 2 (no pagination), 2022.
Article in English | EMBASE | ID: covidwho-2267708
ABSTRACT

Background:

There have been reports of demyelinating syndromes in association with COVID-19 and to a much lesser extent COVID 19 vaccines. The association between demyelination and vaccines, in general, remains controversial. We review a presentation of fulminant demyelination, and discuss antecedent COVID-19 vaccination, the formulation of a broader differential diagnosis and ultimately the pathologic diagnosis. Case presentation An 80-year-old woman presented with seizure, encephalopathy, quadriparesis and ultimately expired. She received a SARS-CoV-2 vaccine one day prior. Imaging revealed contrast enhancing cerebral lesions, longitudinally extensive transverse myelitis. CSF was markedly inflammatory. Pathologic examination of the CNS lesions revealed demyelination and inflammation beyond white matter, not restricted to a perivenular distribution. Conclusion(s) This case depicts a seemingly fulminant course of a diffuse demyelinating syndrome characterized clinicopathologically as Marburg's variant of multiple sclerosis. There are several unique aspects of this case including the extremely rapid course, the unusual evolution of CSF abnormalities, with hypoglycorrhachia and markedly elevated protein. The proximity to vaccination is a pertinent association to document, though we cannot unequivocally prove causation.Copyright © 2022 The Authors
Keywords
COVID-19 vaccine, Encephalomyelitis, Marburg variant, aged, anemia, article, autopsy, body weight loss, brain damage/di [Diagnosis], brain disease, case report, chronic obstructive lung disease, clinical article, coronavirus disease 2019/dt [Drug Therapy], coronavirus disease 2019/pc [Prevention], death, demyelinating disease/di [Diagnosis], demyelination/di [Diagnosis], depression, diffusion weighted imaging, drug safety, electroencephalography, encephalomyelitis/di [Diagnosis], epileptic discharge/di [Diagnosis], female, flaccid paralysis, generalized seizure, headache/si [Side Effect], heart arrest, hemiparesis, human, hyperlipidemia, hypertension, leptomeningitis/di [Diagnosis], lumbar puncture, lung nodule/di [Diagnosis], malaise, medical history, nervous system inflammation/di [Diagnosis], neuroimaging, neurological intensive care unit, night sweat, nuclear magnetic resonance imaging, pain, patient transport, plasmapheresis, pleocytosis/di [Diagnosis], positron emission tomography, quadriplegia, resuscitation, tonic clonic seizure/dt [Drug Therapy], transverse myelitis/di [Diagnosis], treatment duration, tuberculosis/dt [Drug Therapy], vaccination, very elderly, aciclovir/pv [Special Situation for Pharmacovigilance], amphotericin/pv [Special Situation for Pharmacovigilance], ceftriaxone/pv [Special Situation for Pharmacovigilance], ethambutol/dt [Drug Therapy], ethambutol/pv [Special Situation for Pharmacovigilance], immunoglobulin/pv [Special Situation for Pharmacovigilance], isoniazid/dt [Drug Therapy], isoniazid/pv [Special Situation for Pharmacovigilance], levetiracetam/dt [Drug Therapy], levetiracetam/pv [Special Situation for Pharmacovigilance], methylprednisolone/dt [Drug Therapy], methylprednisolone/iv [Intravenous Drug Administration], methylprednisolone/pv [Special Situation for Pharmacovigilance], pyrazinamide/dt [Drug Therapy], pyrazinamide/pv [Special Situation for Pharmacovigilance], rifampicin/dt [Drug Therapy], rifampicin/pv [Special Situation for Pharmacovigilance], tozinameran/ae [Adverse Drug Reaction], tozinameran/dt [Drug Therapy], tozinameran/pv [Special Situation for Pharmacovigilance], vancomycin/pv [Special Situation for Pharmacovigilance]

Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Neuroimmunology Reports Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Neuroimmunology Reports Year: 2022 Document Type: Article