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COVID-19 and liver injury in individuals with obesity.
Lempesis, Ioannis G; Karlafti, Eleni; Papalexis, Petros; Fotakopoulos, George; Tarantinos, Kyriakos; Lekakis, Vasileios; Papadakos, Stavros P; Cholongitas, Evangelos; Georgakopoulou, Vasiliki E.
  • Lempesis IG; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Karlafti E; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht 616 6200, Netherlands.
  • Papalexis P; Department of Emergency, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki 546 21, Greece.
  • Fotakopoulos G; Unit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, National and Kapodistrian University of Athens, Athens 11527, Greece.
  • Tarantinos K; Department of Biomedical Sciences, University of West Attica, Athens 12243, Greece.
  • Lekakis V; Department of Neurosurgery, General University Hospital of Larisa, Larisa 41221, Greece.
  • Papadakos SP; First Pulmonology Department, Sismanogleio Hospital, Athens 15126, Greece.
  • Cholongitas E; Department of Gastroenterology, Laiko General Hospital, National and Kapodistrian University of Athens, Athens 11527, Greece.
  • Georgakopoulou VE; Department of Gastroenterology, Laiko General Hospital, National and Kapodistrian University of Athens, Athens 11527, Greece.
World J Gastroenterol ; 29(6): 908-916, 2023 Feb 14.
Article in English | MEDLINE | ID: covidwho-2268452
ABSTRACT
Coronavirus disease 2019 is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 that manifests as a variety of clinical manifestations, including liver damage commonly detected by a hepatocellular pattern from liver function tests. Liver injury is associated with a worse prognosis overall. Conditions associated with the severity of the disease include obesity and cardiometabolic comorbidities, which are also associated with nonalcoholic fatty liver disease (NAFLD). The presence of NAFLD, similarly to obesity, is associated with an unfavourable impact on the coronavirus disease 2019 outcome. Individuals with these conditions could present with liver damage and elevated liver function tests due to direct viral cytotoxicity, systemic inflammation, ischemic or hypoxic liver damage or drug side effects. However, liver damage in the setting of NAFLD could also be attributed to a pre-existing chronic low-grade inflammation associated with surplus and dysfunctional adipose tissue in these individuals. Here we investigate the hypothesis that a pre-existing inflammatory status is exacerbated after severe acute respiratory syndrome coronavirus 2 infection, which embodies a second hit to the underestimated liver damage.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: World J Gastroenterol Journal subject: Gastroenterology Year: 2023 Document Type: Article Affiliation country: Wjg.v29.i6.908

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: World J Gastroenterol Journal subject: Gastroenterology Year: 2023 Document Type: Article Affiliation country: Wjg.v29.i6.908