Current status and prospect for development of COVID-19 vaccine adjuvants
Journal of Army Medical University
; 44(23):2353-2359, 2022.
Article
in Chinese
| Scopus | ID: covidwho-2268677
ABSTRACT
Vaccines are the most economical and effective means to protect against SARS-CoV-2 infection. Adjuvants are able to enhance antigen-specific immune responses, reduce antigen doses and vaccination times, and reshape adaptive immune responses, which are crucial to improving the protective efficacy of vaccines. In this article, we review the mechanisms and advantages/disadvantages of the adjuvants used in COVID-19 vaccines that have been authorized for emergency use or are undergoing clinical trials around the world, and analyze the issues that must be considered in the application of adjuvants to COVID-19 vaccines. In addition, we put forward suggestions for future research strategies for COVID-19 vaccine adjuvants (1) adjuvants for immunocompromised people, (2) adjuvants for inducing T cell responses, (3) novel mucosal immune adjuvants, and (4) the rational design of combination adjuvant. © 2022 Editorial Office of Journal of Third Military Medical University. All rights reserved.
Full text:
Available
Collection:
Databases of international organizations
Database:
Scopus
Topics:
Vaccines
Language:
Chinese
Journal:
Journal of Army Medical University
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS