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Duration of SARS-CoV-2 Serum-Neutralizing Antibodies Against SARS-CoV-2 Dependent on the Individual.
Li, Jin; Zou, Li; Li, Shaojie; Zou, Ruogu; Fang, Zhixiong; Zhang, Pingan; Li, Huijun; Wang, Shanshan; Ke, Dong; Gao, Peng; Jin, Cuicui; Fang, Cong; Zhou, Ji; He, Ellen; Skog, Sven.
  • Li J; Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, China.
  • Zou L; Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
  • Li S; Department of General Surgery and Hepatobiliary Surgery, Xiangtan Central Hospital, Xiangtan, Hunan, China.
  • Zou R; Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, China.
  • Fang Z; Department of Infectious Disease and Public Health, Xiangtan Central Hospital, Xiangtan, Hunan, China.
  • Zhang P; Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
  • Li H; Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, China.
  • Wang S; Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, China.
  • Ke D; Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
  • Gao P; Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, China.
  • Jin C; Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, China.
  • Fang C; Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, China.
  • Zhou J; Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, China.
  • He E; Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, China.
  • Skog S; Department of Medicine, Shenzhen Ellen-Sven Precision Medicine Institute, Shenzhen, China.
Viral Immunol ; 36(3): 153-162, 2023 04.
Article in English | MEDLINE | ID: covidwho-2268724
ABSTRACT
We investigated the persistence of SARS-CoV-2-specific neutralizing antibodies in serum (CoV-2-SNAb) against the "WH-Human 1" coronavirus in 57 convalescent persons from January 2020 to January 2021. The CoV-2-SNAb response against authentic "WH-Human 1" showed a significant (p < 0.01) neutralizing high effect (≥95%) in the following manner by 94.7% neutralization for up to 6 months, by 73.1% for up to 8 months, and by 31.7% for up to 10 months in correlation with a significant decrease in the concentration of the virus determined by SARS-CoV-2 spike protein extracellular domain and spike-receptor-binding domain (S-RBD). There was neutralizing effect (<95%) when the S-RBD optical density (OD) value was more than 1.0, showing a suitable threshold of S-RBD = 1.0 (antibody-tittering, OD). However, in some convalescent persons, no neutralizing effect (<95%) was observed although the SARS-CoV-2-specific neutralizing antibodies were bound to the S-RBD (OD >1.0). The neutralization of the virus in these cases may not involve S-RBD, but rather B- and T cell memory responses in overall immunity, using the threshold value (OD = 1.0) of S-RBD as a simple and effective method to determine the neutralization effect of the antibody efficacy and use of vaccination in combination with a standard pseudovirus neutralizing assay. We suggest that convalescent persons should contact their physicians 6-month postinfection to test the function of their serum neutralizing antibodies and determine whether administering a SARS-CoV-2 vaccine is necessary to prevent the development of severe illness in the future.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Viral Immunol Journal subject: Allergy and Immunology / Virology Year: 2023 Document Type: Article Affiliation country: Vim.2022.0094

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Viral Immunol Journal subject: Allergy and Immunology / Virology Year: 2023 Document Type: Article Affiliation country: Vim.2022.0094