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Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV across mammals.
Li, Meng; Du, Juan; Liu, Weiqiang; Li, Zihao; Lv, Fei; Hu, Chunyan; Dai, Yichen; Zhang, Xiaoxiao; Zhang, Zhan; Liu, Gaoming; Pan, Qi; Yu, Yang; Wang, Xiao; Zhu, Pingfen; Tan, Xu; Garber, Paul A; Zhou, Xuming.
  • Li M; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Du J; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Liu W; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Li Z; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Lv F; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Hu C; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Dai Y; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhang X; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Zhang Z; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Liu G; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Pan Q; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Yu Y; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Wang X; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Zhu P; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Tan X; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
  • Garber PA; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhou X; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
ISME J ; 17(4): 549-560, 2023 04.
Article in English | MEDLINE | ID: covidwho-2268756
ABSTRACT
Exploring wild reservoirs of pathogenic viruses is critical for their long-term control and for predicting future pandemic scenarios. Here, a comparative in vitro infection analysis was first performed on 83 cell cultures derived from 55 mammalian species using pseudotyped viruses bearing S proteins from SARS-CoV-2, SARS-CoV, and MERS-CoV. Cell cultures from Thomas's horseshoe bats, king horseshoe bats, green monkeys, and ferrets were found to be highly susceptible to SARS-CoV-2, SARS-CoV, and MERS-CoV pseudotyped viruses. Moreover, five variants (del69-70, D80Y, S98F, T572I, and Q675H), that beside spike receptor-binding domain can significantly alter the host tropism of SARS-CoV-2. An examination of phylogenetic signals of transduction rates revealed that closely related taxa generally have similar susceptibility to MERS-CoV but not to SARS-CoV and SARS-CoV-2 pseudotyped viruses. Additionally, we discovered that the expression of 95 genes, e.g., PZDK1 and APOBEC3, were commonly associated with the transduction rates of SARS-CoV, MERS-CoV, and SARS-CoV-2 pseudotyped viruses. This study provides basic documentation of the susceptibility, variants, and molecules that underlie the cross-species transmission of these coronaviruses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chiroptera / Severe acute respiratory syndrome-related coronavirus / Middle East Respiratory Syndrome Coronavirus / COVID-19 Type of study: Prognostic study / Randomized controlled trials Topics: Variants Limits: Animals Language: English Journal: ISME J Journal subject: Microbiology / Environmental Health Year: 2023 Document Type: Article Affiliation country: S41396-023-01368-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chiroptera / Severe acute respiratory syndrome-related coronavirus / Middle East Respiratory Syndrome Coronavirus / COVID-19 Type of study: Prognostic study / Randomized controlled trials Topics: Variants Limits: Animals Language: English Journal: ISME J Journal subject: Microbiology / Environmental Health Year: 2023 Document Type: Article Affiliation country: S41396-023-01368-2