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Nasal and Plasma SARS-CoV-2 RNA Levels are Associated with Timing of Symptom Resolution in the ACTIV-2 Trial of Non-hospitalized Adults with COVID-19.
Li, Yijia; Harrison, Linda J; Chew, Kara W; Currier, Judy S; Wohl, David A; Daar, Eric S; Evering, Teresa H; Wu, Ryan; Giganti, Mark; Ritz, Justin; Javan, Arzhang Cyrus; Coombs, Robert; Moser, Carlee; Hughes, Michael D; Eron, Joseph J; Smith, Davey M; Li, Jonathan Z.
  • Li Y; Brigham and Women's Hospital, Harvard Medical School, Boston, MA  USA.
  • Harrison LJ; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA  USA.
  • Chew KW; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA  USA.
  • Currier JS; David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA  USA.
  • Wohl DA; University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC  USA.
  • Daar ES; Lundquist Institute at Harbor-UCLA Medical Center, Los Angeles, CA  USA.
  • Evering TH; Weill Cornell Medical College, New York, NY  USA.
  • Wu R; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA  USA.
  • Giganti M; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA  USA.
  • Ritz J; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA  USA.
  • Javan AC; National Institutes of Health, Bethesda, MD  USA.
  • Coombs R; Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA  USA.
  • Moser C; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA  USA.
  • Hughes MD; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA  USA.
  • Eron JJ; University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC  USA.
  • Smith DM; Department of Medicine, University of California, San Diego, La Jolla, CA  USA.
  • Li JZ; Brigham and Women's Hospital, Harvard Medical School, Boston, MA  USA.
Clin Infect Dis ; 2022 Oct 10.
Article in English | MEDLINE | ID: covidwho-2268903
ABSTRACT
Acute COVID-19 symptoms limit daily activities, but little is known about its association with SARS-CoV-2 viral burden. In this exploratory analysis of placebo recipients in the ACTIV-2/A5401 platform trial, we showed that high anterior nasal (AN) RNA levels and detectable plasma RNA were associated with delayed symptom improvement.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article