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Hypotheses on Atherogenesis Triggering: Does the Infectious Nature of Atherosclerosis Development Have a Substruction?
Lusta, Konstantin A; Poznyak, Anastasia V; Sukhorukov, Vasily N; Eremin, Ilya I; Nadelyaeva, Irina I; Orekhov, Alexander N.
  • Lusta KA; Institute for Atherosclerosis Research, Osennyaya 4-1-207, 121609 Moscow, Russia.
  • Poznyak AV; Institute for Atherosclerosis Research, Osennyaya 4-1-207, 121609 Moscow, Russia.
  • Sukhorukov VN; Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, 125315 Moscow, Russia.
  • Eremin II; Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, 119991 Moscow, Russia.
  • Nadelyaeva II; Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, 119991 Moscow, Russia.
  • Orekhov AN; Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, 119991 Moscow, Russia.
Cells ; 12(5)2023 02 23.
Article in English | MEDLINE | ID: covidwho-2269996
ABSTRACT
Since the end of the 20th century, it has been clear that atherosclerosis is an inflammatory disease. However, the main triggering mechanism of the inflammatory process in the vascular walls is still unclear. To date, many different hypotheses have been put forward to explain the causes of atherogenesis, and all of them are supported by strong evidence. Among the main causes of atherosclerosis, which underlies these hypotheses, the following can be mentioned lipoprotein modification, oxidative transformation, shear stress, endothelial dysfunction, free radicals' action, homocysteinemia, diabetes mellitus, and decreased nitric oxide level. One of the latest hypotheses concerns the infectious nature of atherogenesis. The currently available data indicate that pathogen-associated molecular patterns from bacteria or viruses may be an etiological factor in atherosclerosis. This paper is devoted to the analysis of existing hypotheses for atherogenesis triggering, and special attention is paid to the contribution of bacterial and viral infections to the pathogenesis of atherosclerosis and cardiovascular disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Communicable Diseases / Atherosclerosis Type of study: Etiology study Topics: Long Covid Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Cells12050707

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Communicable Diseases / Atherosclerosis Type of study: Etiology study Topics: Long Covid Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Cells12050707