SARS-CoV-2 infection clinical picture and outcomes in adults living with HIV: a cohort analysis.
New Microbiol
; 46(1): 18-23, 2023 Feb.
Article
in English
| MEDLINE | ID: covidwho-2270291
ABSTRACT
Existing evidence about HIV and SARS-CoV-2 co-infection has, so far, yield conflicting results. Methods:
This is a cohort, single center, clinical study aimed at identifying possible characteristics of PLWH that could correlate with the risk of acquiring SARS-CoV-2 and would influence the outcome. 155 cases of SARS-CoV-2 infection were compared with 307 PLWH who tested negative. No variable was associated with an increased risk of infection. SARS-CoV-2 PLWH were completely asymptomatic in 20.6% of cases. Factors associated with severe COVID-19 were age (P=0.001), diabetes (P=0.009) hypertension (P=0.004), cardiovascular disease (P=0.001) or an increasing number of chronic co-morbidities (P=0.002); only the first two variables retained statistical significance in a multivariable model. Only older age and a lower CD4 count were statistically associated with death in the multivariate model. Sixteen PLWH not included in the analysis were infected by SARS-Cov-2 after vaccination. In 4 cases the infection was completely asymptomatic, while in the remaining 12 cases the infection was mild and resembled a flu-like syndrome.Conclusions:
No baseline characteristic defines patients at greater risk of SARS-CoV-2 infection. Older age and the presence of multi-comorbidities are risk factors for a severe clinical course. Lower CD4 counts correlate with a fatal outcome.Keywords
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Collection:
International databases
Database:
MEDLINE
Main subject:
HIV Infections
/
Influenza, Human
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Long Covid
/
Vaccines
Limits:
Adult
/
Humans
Language:
English
Journal:
New Microbiol
Journal subject:
Microbiology
Year:
2023
Document Type:
Article
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