Pathogenic and therapeutic roles of cytokines in Kawasaki diseases.
Clin Chim Acta
; 532: 21-28, 2022 Jul 01.
Article
in English
| MEDLINE | ID: covidwho-2270409
ABSTRACT
Infancy and early childhood are the most common ages for acute pyretic Kawasaki disease (KD). Although the etiology remains a mystery, the current concept is that KD is caused by a contagious pathogen that infects the genetically vulnerable and induces an inflammatory mechanism aimed at cardiovascular organs. Resolving the inflammatory process and decreasing the incidence of coronary anomalies, namely coronary aneurysms, are two benefits of high-dose intravenous immunoglobulin (IVIG) administration. The etiology of KD has been linked to a large number of cytokines and treatment strategies to regulate these cytokines have been suggested. This review will focus on the critical role of cytokines in disease development and possible treatment approaches and potential clinical applications.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Mucocutaneous Lymph Node Syndrome
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Limits:
Child, preschool
/
Humans
/
Infant
Language:
English
Journal:
Clin Chim Acta
Year:
2022
Document Type:
Article
Affiliation country:
J.cca.2022.05.015
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