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COVID-19 convalescent plasma boosts early antibody titer and does not influence the adaptive immune response.
McDyer, John F; Azimpouran, Mahzad; Durkalski-Mauldin, Valerie L; Clevenger, Robert G; Yeatts, Sharon D; Deng, Xutao; Barsan, William; Silbergleit, Robert; El Kassar, Nahed; Popescu, Iulia; Dimitrov, Dimiter; Li, Wei; Lyons, Emily J; Lieber, Sophia C; Stone, Mars; Korley, Frederick K; Callaway, Clifton W; Dumont, Larry J; Norris, Philip J.
  • McDyer JF; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Azimpouran M; Vitalant Research Institute, San Francisco, California, USA.
  • Durkalski-Mauldin VL; Medical University of South Carolina, Charleston, South Carolina, USA.
  • Clevenger RG; Medical University of South Carolina, Charleston, South Carolina, USA.
  • Yeatts SD; Medical University of South Carolina, Charleston, South Carolina, USA.
  • Deng X; Vitalant Research Institute, San Francisco, California, USA.
  • Barsan W; Department of Laboratory Medicine, UCSF, San Francisco, California, USA.
  • Silbergleit R; Department of Emergency Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • El Kassar N; Department of Emergency Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • Popescu I; National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA.
  • Dimitrov D; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Li W; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Lyons EJ; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Lieber SC; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Stone M; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Korley FK; Vitalant Research Institute, San Francisco, California, USA.
  • Callaway CW; Department of Laboratory Medicine, UCSF, San Francisco, California, USA.
  • Dumont LJ; Department of Emergency Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • Norris PJ; University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
JCI Insight ; 8(8)2023 04 24.
Article in English | MEDLINE | ID: covidwho-2271561
ABSTRACT
Multiple randomized, controlled clinical trials have yielded discordant results regarding the efficacy of convalescent plasma in outpatients, with some showing an approximately 2-fold reduction in risk and others showing no effect. We quantified binding and neutralizing antibody levels in 492 of the 511 participants from the Clinical Trial of COVID-19 Convalescent Plasma in Outpatients (C3PO) of a single unit of COVID-19 convalescent plasma (CCP) versus saline infusion. In a subset of 70 participants, peripheral blood mononuclear cells were obtained to define the evolution of B and T cell responses through day 30. Binding and neutralizing antibody responses were approximately 2-fold higher 1 hour after infusion in recipients of CCP compared with saline plus multivitamin, but levels achieved by the native immune system by day 15 were almost 10-fold higher than those seen immediately after CCP administration. Infusion of CCP did not block generation of the host antibody response or skew B or T cell phenotype or maturation. Activated CD4+ and CD8+ T cells were associated with more severe disease outcome. These data show that CCP leads to a measurable boost in anti-SARS-CoV-2 antibodies but that the boost is modest and may not be sufficient to alter disease course.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukocytes, Mononuclear / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Jci.insight.167890

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Leukocytes, Mononuclear / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Year: 2023 Document Type: Article Affiliation country: Jci.insight.167890