Your browser doesn't support javascript.
Humoral response to mRNA-based COVID-19 vaccine in patients with immune thrombocytopenia.
Mori, Akio; Onozawa, Masahiro; Kobayashi, Mirei; Tsukamoto, Shihori; Senjo, Hajime; Ishio, Takashi; Yokoyama, Emi; Izumiyama, Koh; Saito, Makoto; Muraki, Haruna; Morioka, Masanobu; Teshima, Takanori; Kondo, Takeshi.
  • Mori A; Blood Disorders Center, Aiiku Hospital, Sapporo, Japan.
  • Onozawa M; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
  • Kobayashi M; Blood Disorders Center, Aiiku Hospital, Sapporo, Japan.
  • Tsukamoto S; Blood Disorders Center, Aiiku Hospital, Sapporo, Japan.
  • Senjo H; Blood Disorders Center, Aiiku Hospital, Sapporo, Japan.
  • Ishio T; Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
  • Yokoyama E; Blood Disorders Center, Aiiku Hospital, Sapporo, Japan.
  • Izumiyama K; Blood Disorders Center, Aiiku Hospital, Sapporo, Japan.
  • Saito M; Blood Disorders Center, Aiiku Hospital, Sapporo, Japan.
  • Muraki H; Blood Disorders Center, Aiiku Hospital, Sapporo, Japan.
  • Morioka M; Division of Laboratory, Aiiku Hospital, Sapporo, Japan.
  • Teshima T; Sapporo Clinical Laboratory, Inc., Sapporo, Japan.
  • Kondo T; Blood Disorders Center, Aiiku Hospital, Sapporo, Japan.
Br J Haematol ; 2022 Nov 28.
Article in English | MEDLINE | ID: covidwho-2272889
ABSTRACT
Data for COVID-19 vaccine response in patients with immune thrombocytopenia (ITP) are very limited. In a study of 28 patients with ITP, anti-severe acute respiratory syndrome coronavirus 2 spike antibody titres were measured after vaccination. The seroconversion rate for ITP patients was 91.3%, comparable to that in healthy controls (HCs). However, the antibody titre in ITP patients was significantly lower than that in HCs and declined with ageing. Furthermore, the antibody titre in ITP patients who received a minimum prednisolone dose of at least 5 mg/day at any time-point at or after initial vaccination was lower than that in other patients.
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Bjh.18578

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Bjh.18578