A feasibility trial of a computerised Spatial Inattention Grasping Home-based Therapy (c-SIGHT) for spatial neglect post-stroke: Trial update

ABSTRACT

Introduction: Spatial neglect (SN) is a debilitating neuropsychological syndrome defined as a failure to respond to stimuli in the side of space opposite to the side of the brain injury. Despite the impact, there are currently no clinically effective rehabilitation methods. Computerised rehabilitation can increase enjoyment and feelings of independence (Morse et al.,2020), thus we developed computerised Spatial Inattention Grasping Home-based Therapy (c-SIGHT) which can remotely record adherence and facilitate self-administration. SIGHT, or visuomotor feedback training, or (grasping-to-lift and balance rods) has been shown to be effective in reducing SN (Rossit et al., 2019). Method(s) This research aims to investigate the feasibility of a randomized controlled trial using c-SIGHT vs. an attentional control, while also exploring experiences of self-administering the therapy at home. This is a two-arm, double-blinded feasibility study intends to recruit 46 stroke survivors with SN and allocate them using minimisation to self-administer c-SIGHT or an attentional control for 30 minutes, twice a day for 10 days at home. Participants complete a set of neuropsychological tests and questionnaires at three time points (baseline, post-training, one-month follow-up) and one semi-structured interview after using c-SIGHT. Primary outcomes are feasibility parameters (recruitment, blinding success, adherence, follow-up rates). Secondary outcomes are changes in neglect, cognition and activities of daily living. Result(s) Since May 2021, the study has opened up at five NHS sites in the East of England. Despite COVID-19 delays, 20 stroke survivors have been recruited, 11 completed baseline assessments, and four have completed the study. Conclusion(s) Other preliminary results (e.g., usability) will be presented.