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Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England.
Nafilyan, Vahé; Bermingham, Charlotte R; Ward, Isobel L; Morgan, Jasper; Zaccardi, Francesco; Khunti, Kamlesh; Stanborough, Julie; Banerjee, Amitava; Doidge, James C.
  • Nafilyan V; Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK. vahe.nafilyan@ons.gov.uk.
  • Bermingham CR; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK. vahe.nafilyan@ons.gov.uk.
  • Ward IL; Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK. charlotte.bermingham@ons.gov.uk.
  • Morgan J; Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK.
  • Zaccardi F; Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK.
  • Khunti K; Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK.
  • Stanborough J; Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK.
  • Banerjee A; Data and Analysis for Social Care and Health, Office for National Statistics, Newport, NP10 8XG, UK.
  • Doidge JC; Institute of Health Informatics, University College London, London, NW1 2DA, UK.
Nat Commun ; 14(1): 1541, 2023 03 27.
Article in English | MEDLINE | ID: covidwho-2273491
ABSTRACT
Several studies have reported associations between COVID-19 vaccination and risk of cardiac diseases, especially in young people; the impact on mortality, however, remains unclear. We use national, linked electronic health data in England to assess the impact of COVID-19 vaccination and positive SARS-CoV-2 tests on the risk of cardiac and all-cause mortality in young people (12 to 29 years) using a self-controlled case series design. Here, we show there is no significant increase in cardiac or all-cause mortality in the 12 weeks following COVID-19 vaccination compared to more than 12 weeks after any dose. However, we find an increase in cardiac death in women after a first dose of non mRNA vaccines. A positive SARS-CoV-2 test is associated with increased cardiac and all-cause mortality among people vaccinated or unvaccinated at time of testing.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Cause of Death / Vaccination / COVID-19 Vaccines / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Adolescent / Adult / Child / Female / Humans / Male / Young adult Country/Region as subject: Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2023 Document Type: Article Affiliation country: S41467-023-36494-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cause of Death / Vaccination / COVID-19 Vaccines / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Adolescent / Adult / Child / Female / Humans / Male / Young adult Country/Region as subject: Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2023 Document Type: Article Affiliation country: S41467-023-36494-0