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Lentiviral Vectors as a Vaccine Platform against Infectious Diseases.
Nemirov, Kirill; Bourgine, Maryline; Anna, François; Wei, Yu; Charneau, Pierre; Majlessi, Laleh.
  • Nemirov K; Pasteur-TheraVectys Joint Lab, Institut Pasteur, Université de Paris, 28 rue du Dr Roux, CEDEX 15, 75724 Paris, France.
  • Bourgine M; Pasteur-TheraVectys Joint Lab, Institut Pasteur, Université de Paris, 28 rue du Dr Roux, CEDEX 15, 75724 Paris, France.
  • Anna F; Pasteur-TheraVectys Joint Lab, Institut Pasteur, Université de Paris, 28 rue du Dr Roux, CEDEX 15, 75724 Paris, France.
  • Wei Y; Pasteur-TheraVectys Joint Lab, Institut Pasteur, Université de Paris, 28 rue du Dr Roux, CEDEX 15, 75724 Paris, France.
  • Charneau P; Pasteur-TheraVectys Joint Lab, Institut Pasteur, Université de Paris, 28 rue du Dr Roux, CEDEX 15, 75724 Paris, France.
  • Majlessi L; Pasteur-TheraVectys Joint Lab, Institut Pasteur, Université de Paris, 28 rue du Dr Roux, CEDEX 15, 75724 Paris, France.
Pharmaceutics ; 15(3)2023 Mar 05.
Article in English | MEDLINE | ID: covidwho-2273942
ABSTRACT
Lentiviral vectors are among the most effective viral vectors for vaccination. In clear contrast to the reference adenoviral vectors, lentiviral vectors have a high potential for transducing dendritic cells in vivo. Within these cells, which are the most efficient at activating naive T cells, lentiviral vectors induce endogenous expression of transgenic antigens that directly access antigen presentation pathways without the need for external antigen capture or cross-presentation. Lentiviral vectors induce strong, robust, and long-lasting humoral, CD8+ T-cell immunity and effective protection against several infectious diseases. There is no pre-existing immunity to lentiviral vectors in the human population and the very low pro-inflammatory properties of these vectors pave the way for their use in mucosal vaccination. In this review, we have mainly summarized the immunological aspects of lentiviral vectors, their recent optimization to induce CD4+ T cells, and our recent data on lentiviral vector-based vaccination in preclinical models, including prophylaxis against flaviviruses, SARS-CoV-2, and Mycobacterium tuberculosis.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Topics: Vaccines Language: English Year: 2023 Document Type: Article Affiliation country: Pharmaceutics15030846

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials Topics: Vaccines Language: English Year: 2023 Document Type: Article Affiliation country: Pharmaceutics15030846