Your browser doesn't support javascript.
Neuropathological features of SARS-CoV-2 delta and omicron variants.
Normandin, Erica; Valizadeh, Navid; Rudmann, Emily A; Uddin, Rockib; Dobbins, Sabrina T; MacInnis, Bronwyn L; Padera, Robert F; Siddle, Katherine J; Lemieux, Jacob E; Sabeti, Pardis C; Mukerji, Shibani S; Solomon, Isaac H.
  • Normandin E; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Valizadeh N; Division of Neuroimmunology and Neuro-infectious Diseases, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Rudmann EA; Division of Neuroimmunology and Neuro-infectious Diseases, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Uddin R; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Dobbins ST; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • MacInnis BL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Padera RF; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Siddle KJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Lemieux JE; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Sabeti PC; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Mukerji SS; Division of Neuroimmunology and Neuro-infectious Diseases, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Solomon IH; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
J Neuropathol Exp Neurol ; 82(4): 283-295, 2023 03 20.
Article in English | MEDLINE | ID: covidwho-2274412
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continually evolving resulting in variants with increased transmissibility, more severe disease, reduced effectiveness of treatments or vaccines, or diagnostic detection failure. The SARS-CoV-2 Delta variant (B.1.617.2 and AY lineages) was the dominant circulating strain in the United States from July to mid-December 2021, followed by the Omicron variant (B.1.1.529 and BA lineages). Coronavirus disease 2019 (COVID-19) has been associated with neurological sequelae including loss of taste/smell, headache, encephalopathy, and stroke, yet little is known about the impact of viral strain on neuropathogenesis. Detailed postmortem brain evaluations were performed for 22 patients from Massachusetts, including 12 who died following infection with Delta variant and 5 with Omicron variant, compared to 5 patients who died earlier in the pandemic. Diffuse hypoxic injury, occasional microinfarcts and hemorrhage, perivascular fibrinogen, and rare lymphocytes were observed across the 3 groups. SARS-CoV-2 protein and RNA were not detected in any brain samples by immunohistochemistry, in situ hybridization, or real-time quantitative PCR. These results, although preliminary, demonstrate that, among a subset of severely ill patients, similar neuropathological features are present in Delta, Omicron, and non-Delta/non-Omicron variant patients, suggesting that SARS-CoV-2 variants are likely to affect the brain by common neuropathogenic mechanisms.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Stroke / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Long Covid / Vaccines / Variants Limits: Humans Language: English Journal: J Neuropathol Exp Neurol Year: 2023 Document Type: Article Affiliation country: Jnen

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Stroke / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Long Covid / Vaccines / Variants Limits: Humans Language: English Journal: J Neuropathol Exp Neurol Year: 2023 Document Type: Article Affiliation country: Jnen