The causal effect of being born extremely preterm or extremely low birthweight on neurodevelopment and social-emotional development at 2 years.
Acta Paediatr
; 111(1): 107-114, 2022 Jan.
Article
in English
| MEDLINE | ID: covidwho-2274902
ABSTRACT
AIM:
To assess the causal effect of being born extremely preterm (EP; <28 weeks' gestation) or extremely low birthweight (ELBW; <1000 g), compared with being born at term, on neurodevelopment and social-emotional development at 2 years' corrected age.METHODS:
Prospective geographical cohort study of children born EP/ELBW over 12 months in 2016 from Victoria, Australia, and term-born controls. Children were assessed at 2 years' corrected age with the Bayley Scales of Infant and Toddler Development-3rd edition and the Infant-Toddler Social and Emotional Assessment. Delay was defined as <-1 standard deviation relative to the mean of controls. The estimand of interest was the mean difference/odds ratio (OR) between the EP/ELBW and control groups estimated using linear/logistic regression, adjusted for multiple pregnancy and social risk.RESULTS:
A total of 205 EP/ELBW and 201 controls were assessed at 2 years. Delay/concerns were more common in the EP/ELBW group compared with controls, for cognitive (OR 3.7 [95% confidence interval 2.3, 6.0]), language (5.3 [3.1, 9.0]) and motor (3.9 [2.3, 6.3]) development, and social-emotional competence (4.1 [1.6, 10.2]).CONCLUSION:
Being born EP/ELBW has an adverse effect on cognitive, language and motor development, and social-emotional competence at 2 years' corrected age. Close developmental surveillance, including social-emotional development, is recommended.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Infant, Extremely Low Birth Weight
/
Infant, Extremely Premature
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Child
/
Female
/
Humans
/
Infant
/
Infant, Newborn
/
Pregnancy
Country/Region as subject:
Oceania
Language:
English
Journal:
Acta Paediatr
Year:
2022
Document Type:
Article
Affiliation country:
Apa.16098
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