Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19.
Aging Clin Exp Res
; 35(5): 1139-1143, 2023 May.
Article
in English
| MEDLINE | ID: covidwho-2277429
ABSTRACT
BACKGROUND:
Only limited studies analyzed a possible relationship between frailty and infections. Our aim was to investigate the possible association between higher multidimensional prognostic index (MPI) values, a tool for evaluating multidimensional frailty, and the prevalence of infectious diseases, including antibiotics' cost and the prevalence of MDR (multidrug resistance) pathogens.METHODS:
Older patients, affected by COVID-19, were enrolled in the hospital of Palermo over four months.RESULTS:
112 participants (mean age 77.6, 55.4% males) were included. After adjusting for potential confounders, frailer participants had a higher odds of any positivity to pathogens (prevalence 61.5%, odds ratio = 15.56, p < 0.0001) compared to a prevalence of 8.6% in more robust, including MDR, and a higher costs in antibiotics.CONCLUSIONS:
Higher MPI values, indicating frailer subjects, were associated with a higher prevalence of infections, particularly of MDR pathogens, and a consequent increase in antibiotics' cost.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Frailty
/
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Aging Clin Exp Res
Journal subject:
Geriatrics
Year:
2023
Document Type:
Article
Affiliation country:
S40520-023-02386-y
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