Development of animal models for emerging infectious diseases by breaking the barrier of species susceptibility to human pathogens.
Emerg Microbes Infect
; 12(1): 2178242, 2023 Dec.
Article
in English
| MEDLINE | ID: covidwho-2278716
ABSTRACT
Outbreaks of emerging infectious diseases pose a serious threat to public health security, human health and economic development. After an outbreak, an animal model for an emerging infectious disease is urgently needed for studying the etiology, host immune mechanisms and pathology of the disease, evaluating the efficiency of vaccines or drugs against infection, and minimizing the time available for animal model development, which is usually hindered by the nonsusceptibility of common laboratory animals to human pathogens. Thus, we summarize the technologies and methods that induce animal susceptibility to human pathogens, which include viral receptor humanization, pathogen-targeted tissue humanization, immunodeficiency induction and screening for naturally susceptible animal species. Furthermore, the advantages and deficiencies of animal models developed using each method were analyzed, and these will guide the selection of susceptible animals and potentially reduce the time needed to develop animal models during epidemics.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vaccines
/
Communicable Diseases, Emerging
Type of study:
Etiology study
/
Experimental Studies
/
Observational study
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Emerg Microbes Infect
Year:
2023
Document Type:
Article
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