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The outcome of COVID-19 in children with chronic lung disease: Systematic review and meta-analyses.
Sallih, Aimi Suhaili Mohd; Wee, Mae Wae; Zaki, Rafdzah A; Hng, Shih Ying; Eg, Kah Peng; Nathan, Anna M; de Bruyne, Jessie A.
  • Sallih ASM; Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Wee MW; Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Zaki RA; Department of Social and Preventive Medicine, Centre for Epidemiology and Evidence-Based Practice, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Hng SY; Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Eg KP; Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Nathan AM; Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • de Bruyne JA; Department of Paediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Pediatr Pulmonol ; 58(6): 1784-1797, 2023 06.
Article in English | MEDLINE | ID: covidwho-2279479
ABSTRACT

BACKGROUND:

Few studies have examined the impact of Coronavirus disease 2019 (COVID-19) infection on children with chronic lung disease (CLD).

OBJECTIVE:

To perform a systematic review and meta-analysis to determine the prevalence, risk factors for contracting COVID-19, and complications of COVID-19, in children with CLD.

METHODS:

This systematic review was based on articles published between January 1, 2020 and July 25, 2022. Children under 18 years old, with any CLD and infected with COVID-19 were included.

RESULTS:

Ten articles involving children with asthma and four involving children with cystic fibrosis (CF) were included in the analyses. The prevalence of COVID-19 in children with asthma varied between 0.14% and 19.1%. The use of inhaled corticosteroids (ICS) was associated with reduced risk for COVID-19 (risk ratio [RR] 0.60, 95% confidence interval [CI] 0.40-0.90). Uncontrolled asthma, younger age, AND moderate-severe asthma were not significant risk factors for contracting COVID-19. Children with asthma had an increased risk for hospitalization (RR 1.62, 95% CI 1.07-2.45) but were not more likely to require assisted ventilation (RR 0.51, 95% CI 0.14-1.90). The risk of COVID-19 infection among children with CF was <1%. Posttransplant and cystic fibrosis-related diabetes mellitus (CFRDM) patients were at an increased risk for hospitalization and intensive care treatment.

CONCLUSION:

Hospitalizations were higher in children with asthma with COVID-19 infection. However, using ICS reduced the risk of COVID-19 infection. As for CF, postlung transplantation and CFRDM were risk factors for severe disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Anti-Asthmatic Agents / Cystic Fibrosis / COVID-19 Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Adolescent / Child / Humans Language: English Journal: Pediatr Pulmonol Journal subject: Pediatrics Year: 2023 Document Type: Article Affiliation country: Ppul.26403

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Anti-Asthmatic Agents / Cystic Fibrosis / COVID-19 Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Adolescent / Child / Humans Language: English Journal: Pediatr Pulmonol Journal subject: Pediatrics Year: 2023 Document Type: Article Affiliation country: Ppul.26403