The outcome of COVID-19 in children with chronic lung disease: Systematic review and meta-analyses.
Pediatr Pulmonol
; 58(6): 1784-1797, 2023 06.
Article
in English
| MEDLINE | ID: covidwho-2279479
ABSTRACT
BACKGROUND:
Few studies have examined the impact of Coronavirus disease 2019 (COVID-19) infection on children with chronic lung disease (CLD).OBJECTIVE:
To perform a systematic review and meta-analysis to determine the prevalence, risk factors for contracting COVID-19, and complications of COVID-19, in children with CLD.METHODS:
This systematic review was based on articles published between January 1, 2020 and July 25, 2022. Children under 18 years old, with any CLD and infected with COVID-19 were included.RESULTS:
Ten articles involving children with asthma and four involving children with cystic fibrosis (CF) were included in the analyses. The prevalence of COVID-19 in children with asthma varied between 0.14% and 19.1%. The use of inhaled corticosteroids (ICS) was associated with reduced risk for COVID-19 (risk ratio [RR] 0.60, 95% confidence interval [CI] 0.40-0.90). Uncontrolled asthma, younger age, AND moderate-severe asthma were not significant risk factors for contracting COVID-19. Children with asthma had an increased risk for hospitalization (RR 1.62, 95% CI 1.07-2.45) but were not more likely to require assisted ventilation (RR 0.51, 95% CI 0.14-1.90). The risk of COVID-19 infection among children with CF was <1%. Posttransplant and cystic fibrosis-related diabetes mellitus (CFRDM) patients were at an increased risk for hospitalization and intensive care treatment.CONCLUSION:
Hospitalizations were higher in children with asthma with COVID-19 infection. However, using ICS reduced the risk of COVID-19 infection. As for CF, postlung transplantation and CFRDM were risk factors for severe disease.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Asthma
/
Anti-Asthmatic Agents
/
Cystic Fibrosis
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Adolescent
/
Child
/
Humans
Language:
English
Journal:
Pediatr Pulmonol
Journal subject:
Pediatrics
Year:
2023
Document Type:
Article
Affiliation country:
Ppul.26403
Similar
MEDLINE
...
LILACS
LIS