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Remdesivir Use in Pediatric Patients for SARS-CoV-2 Treatment: Single Academic Center Study.
Samuel, Allison M; Hacker, Larissa L; Zebracki, Jessica; Bogenschutz, Monica C; Schulz, Lucas; Strayer, Jill; Vanderloo, Joshua P; Cengiz, Pelin; Henderson, Sheryl.
  • Samuel AM; From the Department of Pharmacy, University of Wisconsin Health, Madison, Wisconsin.
  • Hacker LL; From the Department of Pharmacy, University of Wisconsin Health, Madison, Wisconsin.
  • Zebracki J; From the Department of Pharmacy, University of Wisconsin Health, Madison, Wisconsin.
  • Bogenschutz MC; From the Department of Pharmacy, University of Wisconsin Health, Madison, Wisconsin.
  • Schulz L; From the Department of Pharmacy, University of Wisconsin Health, Madison, Wisconsin.
  • Strayer J; From the Department of Pharmacy, University of Wisconsin Health, Madison, Wisconsin.
  • Vanderloo JP; From the Department of Pharmacy, University of Wisconsin Health, Madison, Wisconsin.
  • Cengiz P; Division of Pediatric Critical Care Medicine.
  • Henderson S; Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Pediatr Infect Dis J ; 42(4): 310-314, 2023 04 01.
Article in English | MEDLINE | ID: covidwho-2279579
ABSTRACT

BACKGROUND:

Millions of children in the United States have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with many infections leading to hospitalization. For pediatric patients, especially younger children, treatment options are limited. Remdesivir has demonstrated a positive safety and efficacy profile in adults, but little data is published regarding remdesivir use in pediatric patients. Additional data for SARS-CoV-2 treatments in pediatric patients is required to prevent further SARS-CoV-2-related morbidity and mortality. At a single pediatric academic medical center, the safety and efficacy of remdesivir was evaluated.

METHODS:

A retrospective review of patients admitted to a pediatric academic medical center who received remdesivir over a 17-month period was completed. All pediatric patients who received at least 1 dose of remdesivir were included. Safety and efficacy were assessed using national organization's definitions of clinical improvement, bradycardia, hypertension, acute kidney injury and drug-induced liver injury.

RESULTS:

There were 48 pediatric patients included in this study with 29% of patients admitted to the pediatric intensive care unit. Less than one-third of patients received the full treatment course of remdesivir, with over half of patients not completing therapy due to symptomatic improvement or hospital discharge. Majority of patients required some level of supplemental oxygen support. The median World Health Organization score was consistent throughout all 5 days of therapy. No patients experienced significant bradycardia, hypertension, acute kidney injury, or drug-induced liver injury.

CONCLUSIONS:

Remdesivir may correlate with clinical stability or improvement and demonstrates safety when used in pediatric patients. A randomized controlled trial is needed to confirm these findings.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Child / Humans Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Child / Humans Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2023 Document Type: Article