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The role of immunomodulatory medications in the treatment of COVID-19.
Sattui, Sebastian E; Crow, Mary K; Navarro-Millán, Iris.
  • Sattui SE; Division of Rheumatology, Department of Medicine, Hospital for Special Surgery.
  • Crow MK; Division of Rheumatology, Department of Medicine, Hospital for Special Surgery.
  • Navarro-Millán I; Division of Rheumatology, Department of Medicine, Hospital for Special Surgery.
Curr Opin Rheumatol ; 33(5): 431-445, 2021 09 01.
Article in English | MEDLINE | ID: covidwho-2279944
ABSTRACT
PURPOSE OF REVIEW Given the role of inflammation in severe forms of COVID-19, glucocorticoids and disease-modifying antirheumatic drugs (DMARDs) have been assessed as potential COVID-19 therapies. RECENT

FINDINGS:

Randomized controlled trials (RCTs) have shown that glucocorticoids reduce mortality in severe COVID-19. RCTs of DMARDs have shown mixed results varying on intervention and inclusion criteria. DMARDs, including colchicine or biologic agents, may improve COVID-19 outcomes in specific patient populations.

SUMMARY:

Glucocorticoids are an effective treatment for the management of severe COVID-19. Further studies are needed to better define the patient populations who could benefit from DMARD use, as well as provide guidance regarding the timing of these interventions.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Antirheumatic Agents / COVID-19 Drug Treatment Type of study: Experimental Studies / Randomized controlled trials Limits: Humans Language: English Journal: Curr Opin Rheumatol Journal subject: Rheumatology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Antirheumatic Agents / COVID-19 Drug Treatment Type of study: Experimental Studies / Randomized controlled trials Limits: Humans Language: English Journal: Curr Opin Rheumatol Journal subject: Rheumatology Year: 2021 Document Type: Article