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Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance.
Scaramuzzo, Gaetano; Nucera, Francesco; Asmundo, Alessio; Messina, Roberto; Mari, Matilde; Montanaro, Federica; Johansen, Matt D; Monaco, Francesco; Fadda, Guido; Tuccari, Giovanni; Hansbro, Nicole G; Hansbro, Philip M; Hansel, Trevor T; Adcock, Ian M; David, Antonio; Kirkham, Paul; Caramori, Gaetano; Volta, Carlo Alberto; Spadaro, Savino.
  • Scaramuzzo G; Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
  • Nucera F; Department of Emergency, Section of Intensive Care and Anesthesia, Azienda Ospedaliera-Universitaria Sant'Anna, Ferrara, Italy.
  • Asmundo A; Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy.
  • Messina R; Medicina Legale, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy.
  • Mari M; Intensive Care Unit, Dipartimento di Patologia Umana e dell'Età Evolutiva Gaetano Barresi, Università di Messina, Messina, Italy.
  • Montanaro F; Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
  • Johansen MD; Department of Emergency, Section of Intensive Care and Anesthesia, Azienda Ospedaliera-Universitaria Sant'Anna, Ferrara, Italy.
  • Monaco F; Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
  • Fadda G; Department of Emergency, Section of Intensive Care and Anesthesia, Azienda Ospedaliera-Universitaria Sant'Anna, Ferrara, Italy.
  • Tuccari G; Centre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW, Australia.
  • Hansbro NG; Chirurgia Toracica, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy.
  • Hansbro PM; Section of Pathological Anatomy, Department of Human Pathology of Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, Italy.
  • Hansel TT; Section of Pathological Anatomy, Department of Human Pathology of Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, Italy.
  • Adcock IM; Centre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW, Australia.
  • David A; Centre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW, Australia.
  • Kirkham P; Medical Research Council and Asthma, UK Centre in Allergic Mechanisms of Asthma, London, UK.
  • Caramori G; Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
  • Volta CA; Intensive Care Unit, Dipartimento di Patologia Umana e dell'Età Evolutiva Gaetano Barresi, Università di Messina, Messina, Italy.
  • Spadaro S; Department of Biomedical Sciences, Faculty of Sciences and Engineering, University of Wolverhampton, West Midlands, Wolverhampton, UK.
J Inflamm (Lond) ; 20(1): 11, 2023 Mar 20.
Article in English | MEDLINE | ID: covidwho-2280045
ABSTRACT
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: J Inflamm (Lond) Year: 2023 Document Type: Article Affiliation country: S12950-023-00333-2

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: J Inflamm (Lond) Year: 2023 Document Type: Article Affiliation country: S12950-023-00333-2