A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens.
Nano Lett
; 23(9): 3701-3707, 2023 05 10.
Article
in English
| MEDLINE | ID: covidwho-2280132
ABSTRACT
Speed is key during infectious disease outbreaks. It is essential, for example, to identify critical host binding factors to pathogens as fast as possible. The complexity of host plasma membrane is often a limiting factor hindering fast and accurate determination of host binding factors as well as high-throughput screening for neutralizing antimicrobial drug targets. Here, we describe a multiparametric and high-throughput platform tackling this bottleneck and enabling fast screens for host binding factors as well as new antiviral drug targets. The sensitivity and robustness of our platform were validated by blocking SARS-CoV-2 particles with nanobodies and IgGs from human serum samples.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Nano Lett
Year:
2023
Document Type:
Article
Affiliation country:
Acs.nanolett.2c04884
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