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Safety and Effectiveness of SA58 Nasal Spray Against COVID-19 Infection in Medical Personnel: An Open-Label, Blank-Controlled Study - Hohhot City, Inner Mongolia Autonomous Region, China, 2022.
Si, Shujie; Jin, Canrui; Li, Jianping; Cao, Yunlong; Kan, Biao; Xue, Feng; Xie, Xiaoliang Sunney; Fang, Liang; Zeng, Gang; Zhang, Shuo; Hu, Yaling; Dong, Xiaoping.
  • Si S; Pharmacy Department, Inner Mongolia Fourth Hospital, Hohhot City, Inner Mongolia Autonomous Region, China.
  • Jin C; Clinical Research and Development Department, Sinovac Biotech Co., Ltd., Beijing, China.
  • Li J; Clinical Research and Development Department, Sinovac Biotech Co., Ltd., Beijing, China.
  • Cao Y; Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China.
  • Kan B; Changping Laboratory, Beijing, China.
  • Xue F; State Key Laboratory for Infectious Disease Prevention and Control, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
  • Xie XS; Research and Development Department, Sinovac Life Sciences Co., Ltd., Beijing, China.
  • Fang L; Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China.
  • Zeng G; Changping Laboratory, Beijing, China.
  • Zhang S; Clinical Research and Development Department, Sinovac Biotech Co., Ltd., Beijing, China.
  • Hu Y; Clinical Research and Development Department, Sinovac Biotech Co., Ltd., Beijing, China.
  • Dong X; Inner Mongolia Blood Center, Hohhot City, Inner Mongolia Autonomous Region, China.
China CDC Wkly ; 5(10): 218-222, 2023 Mar 10.
Article in English | MEDLINE | ID: covidwho-2281340
ABSTRACT
What is already known about this topic? The active ingredient of the SA58 Nasal Spray is a broad-spectrum neutralizing antibody with a high neutralizing capacity against different Omicron sub-variants in vitro studies. What is added by this report? This study demonstrated the safety and effectiveness of SA58 Nasal Spray against coronavirus disease 2019 (COVID-19) infection in medical personnel for the first time. What are the implications for public health practice? This study provides an effective approach for the public to reduce their risk of COVID-19 infection. The findings of this research have the potential to significantly reduce the risk of infection and limit human-to-human transmission in the event of a COVID-19 outbreak.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Variants Language: English Journal: China CDC Wkly Year: 2023 Document Type: Article Affiliation country: Ccdcw2023.040

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Variants Language: English Journal: China CDC Wkly Year: 2023 Document Type: Article Affiliation country: Ccdcw2023.040