Guillain-Barré syndrome AMSAN variant in a 90-year-old woman after COVID-19: a case report.
BMC Geriatr
; 23(1): 114, 2023 03 01.
Article
in English
| MEDLINE | ID: covidwho-2281391
ABSTRACT
BACKGROUND:
Guillain-Barré syndrome (GBS) is an inflammatory disease of the peripheral nervous system characterized by rapidly evolving polyneuropathy caused by autoimmune demyelination and/or axonal degeneration. Since SARS-CoV-2 outbreak, several GBS cases following exposure to coronavirus disease-2019 (COVID-19) have been reported in literature, raising the concern of the latter being a potential trigger event for GBS. CASE PRESENTATION We report the case of a 90-year-old Caucasian woman who was admitted to our hospital because of fatigue, worsening gait and leg strength, dysphonia, dysarthria and dysphagia, started 3 weeks after being exposed to COVID-19. Based on clinical presentation GBS was suspected, so she performed a lumbar puncture and electromyography, which confirmed the diagnosis of acute motor and sensory axonal neuropathy (AMSAN) variant. We administered high dose of intravenous immunoglobulin with slight neurological improvement. However, after 2 weeks of hospitalization with maximization of care, her physical condition worsen, manifesting severe frailty. The patient was discharged with home support services for managing parenteral nutrition and intense scheduled physiotherapy. A few days later, the patient experienced a further decline in her clinical condition and died at home.CONCLUSIONS:
To the best of our knowledge, we report the oldest woman with GBS AMSAN variant after COVID-19 described in the existing literature. Our case supports further research aimed at improving recognition, characterization and prompt management of neurological diseases related to COVID-19 in older patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Deglutition Disorders
/
Guillain-Barre Syndrome
/
COVID-19
Type of study:
Case report
/
Prognostic study
Topics:
Variants
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
BMC Geriatr
Journal subject:
Geriatrics
Year:
2023
Document Type:
Article
Affiliation country:
S12877-023-03833-1
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