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Guillain-Barré syndrome AMSAN variant in a 90-year-old woman after COVID-19: a case report.
Sidoli, Chiara; Bruni, Adriana Antonella; Beretta, Simone; Mazzola, Paolo; Bellelli, Giuseppe.
  • Sidoli C; School of Medicine and Surgery, University of Milano-Bicocca, U8 Building, Floor 4, Lab 4045, Via Cadore, 48, 20900, Monza, MB, Italy.
  • Bruni AA; Acute Geriatrics Unit, San Gerardo hospital ASST Monza, Monza, MB, Italy.
  • Beretta S; School of Medicine and Surgery, University of Milano-Bicocca, U8 Building, Floor 4, Lab 4045, Via Cadore, 48, 20900, Monza, MB, Italy.
  • Mazzola P; Neurology Unit, San Gerardo hospital ASST Monza, Monza, MB, Italy.
  • Bellelli G; NeuroMI - Milan Center for Neuroscience, Clinical Neurosciences Research Area, Milan, MI, Italy.
BMC Geriatr ; 23(1): 114, 2023 03 01.
Article in English | MEDLINE | ID: covidwho-2281391
ABSTRACT

BACKGROUND:

Guillain-Barré syndrome (GBS) is an inflammatory disease of the peripheral nervous system characterized by rapidly evolving polyneuropathy caused by autoimmune demyelination and/or axonal degeneration. Since SARS-CoV-2 outbreak, several GBS cases following exposure to coronavirus disease-2019 (COVID-19) have been reported in literature, raising the concern of the latter being a potential trigger event for GBS. CASE PRESENTATION We report the case of a 90-year-old Caucasian woman who was admitted to our hospital because of fatigue, worsening gait and leg strength, dysphonia, dysarthria and dysphagia, started 3 weeks after being exposed to COVID-19. Based on clinical presentation GBS was suspected, so she performed a lumbar puncture and electromyography, which confirmed the diagnosis of acute motor and sensory axonal neuropathy (AMSAN) variant. We administered high dose of intravenous immunoglobulin with slight neurological improvement. However, after 2 weeks of hospitalization with maximization of care, her physical condition worsen, manifesting severe frailty. The patient was discharged with home support services for managing parenteral nutrition and intense scheduled physiotherapy. A few days later, the patient experienced a further decline in her clinical condition and died at home.

CONCLUSIONS:

To the best of our knowledge, we report the oldest woman with GBS AMSAN variant after COVID-19 described in the existing literature. Our case supports further research aimed at improving recognition, characterization and prompt management of neurological diseases related to COVID-19 in older patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Deglutition Disorders / Guillain-Barre Syndrome / COVID-19 Type of study: Case report / Prognostic study Topics: Variants Limits: Aged / Female / Humans Language: English Journal: BMC Geriatr Journal subject: Geriatrics Year: 2023 Document Type: Article Affiliation country: S12877-023-03833-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Deglutition Disorders / Guillain-Barre Syndrome / COVID-19 Type of study: Case report / Prognostic study Topics: Variants Limits: Aged / Female / Humans Language: English Journal: BMC Geriatr Journal subject: Geriatrics Year: 2023 Document Type: Article Affiliation country: S12877-023-03833-1