The effect of N-acetylcysteine as adjuvant therapy of hypoxemia in COVID-19 patients, assessed by interleukin-6 level and PaO2/FiO2 ratio
Jurnal Respirologi Indonesia
; 42(3):226-236, 2022.
Article
in English
| CAB Abstracts | ID: covidwho-2281537
ABSTRACT
Background:
Interleukin 6 (IL-6) is a cytokine that plays an essential role in lung damage and mortality. Arterial-to-inspired oxygen (PaO2/FiO2) ratio, also known as the Horowitz index, is a measure of hypoxemia in respiratory failure. N-Acetylcysteine (NAC) might be helpful in managing coronavirus disease 2019 (COVID-19) patients by decreasing the cytokine storm, which will lead to a decrease in disease severity. This study aims to analyze the effect of NAC as adjuvant therapy on IL-6 level and PaO2/FiO2 ratio in COVID-19 patients.Methods:
This is a quasi-experimental, non-equivalent control group designed study of confirmed COVID-19 patients moderate to critical in Saiful Anwar Hospital Malang. Seventy-five patients received NAC intravenously 5000 mg/72 hours as adjuvant therapy for seven days, and 16 subjects in the control group. IL-6 level and PaO2/FiO2 ratio were measured on day one and day 8 in both groups from blood samples. Wilcoxon, Mann-Whitney U Test, and Pearson correlation were conducted for statistical analysis.Results:
The decrease in IL-6 level on days 1 to 8 in the NAC group is significantly lower (94.49+or-253.51) than in the control group (P=0.002). The increase in PaO2/FiO2 ratio from day 1 to day 8 in the NAC group is significantly improving (126.94+or-76.05), the same as the control group (P < 0.001). There is a weak correlation between IL-6 level and PaO2/FiO2 ratio after administration of NAC (r=0.154, P=0.186).Conclusion:
There is a significant decrease in IL-6 level after administration of NAC. NAC has no significant effect on hypoxemia in COVID-19 patients.
Prion; Viral; Bacterial and Fungal Pathogens of Humans [VV210], Non-communicable Human Diseases and Injuries [VV600], Human Immunology and Allergology [VV055], Nutrition related Disorders and Therapeutic Nutrition [VV130], interleukin 6, human diseases, coronavirus disease 2019, patients, blood analysis, mortality, respiratory diseases, risk factors, acetylcysteine, man, Severe acute respiratory syndrome coronavirus 2, Homo, Hominidae, primates, mammals, vertebrates, Chordata, animals, eukaryotes, Severe acute respiratory syndrome-related coronavirus, Betacoronavirus, Coronavirinae, Coronaviridae, Nidovirales, positive-sense ssRNA Viruses, ssRNA Viruses, RNA Viruses, viruses, SARS-CoV-2, death rate, lung diseases
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Experimental Studies
Language:
English
Journal:
Jurnal Respirologi Indonesia
Year:
2022
Document Type:
Article
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