IMPACT OF STATINS ON THE CLINICAL COURSE OF COVID-19-ASSOCIATED PNEUMONIA IN UNVACCINATED PATIENTS WITH ARTERIAL HYPERTENSION.
Wiad Lek
; 76(2): 311-319, 2023.
Article
in English
| MEDLINE | ID: covidwho-2281811
ABSTRACT
OBJECTIVE:
Theaim:
To assess the impact of statins on the severity and lethality rate in hypertensive patients with COVID-19-associated pneumonia. PATIENTS ANDMETHODS:
Materials andmethods:
106 unvaccinated hypertensive patients were enrolled in the study. 29 (27.4%) patients took statins.RESULTS:
Results:
Statins were not associated with reduced risks of lethality (relative risk (RR), 0.24; [95%CI, 0.03-1.79], p=0.16), decline in oxygen saturation <92% during the inpatient stay (RR, 0.70 [95%CI, 0.39-1.28], p=0.25) and need for supplemental oxygen (RR, 0.84; [95%CI, 0.51-1.37], p=0.48). There was no significant difference in the median length of in-hospital stay between the patients taking statins (14.0 [10.0-15.0] days) and patients, which didn't take statins (13.0 [9.0-18.0] days) (p=0.76). However, subgroup analysis showed that statins reduced the risk of decline in oxygen saturation <92% in patients aged 65 years and older with body mass index $ 25.0 kg/m2 (RR, 0.33 [95%CI, 0.11-0.92], p=0.03).CONCLUSION:
Conclusions:
Statins didn't a#ect the severity and lethality rate in hypertensive patients with COVID-19-associated pneumonia. Subgroup analysis showed that statin use was associated with a decrease in morbidity of patients aged 65 years and older with BMI $25.0 kg/m2 hospitalized for COVID-19-associated pneumonia.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
COVID-19
/
Hypertension
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Wiad Lek
Journal subject:
Medicine
Year:
2023
Document Type:
Article
Affiliation country:
WLek202302110
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