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Real-time whole genome sequencing to guide patient-tailored therapy of SARS-CoV-2 infection.
Snell, Luke B; Medina-Alcolea, Adela; Charalampous, Themoula; Alder, Christopher; Williams, Tom G S; Flaviani, Flavia; Batra, Rahul; Bakrania, Prijay; Thangarajah, Rajeni; Neil, Stuart J D; van Nispen Tot Pannerden, Claire; Botgros, Alina; Aarons, Emma; Douthwaite, Samuel T; Edgeworth, Jonathan D; Nebbia, Gaia.
  • Snell LB; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Medina-Alcolea A; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Charalampous T; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Alder C; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Williams TGS; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Flaviani F; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Batra R; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Bakrania P; Department of Pharmacy, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Thangarajah R; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Neil SJD; Department of Pharmacy, Guy's and St Thomas' NHS Foundation Trust, UK.
  • van Nispen Tot Pannerden C; Department of Infectious Diseases, King's College London, UK.
  • Botgros A; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Aarons E; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Douthwaite ST; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Edgeworth JD; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
  • Nebbia G; Department of Infection, Guy's and St Thomas' NHS Foundation Trust, UK.
Clin Infect Dis ; 2022 Nov 03.
Article in English | MEDLINE | ID: covidwho-2281964
ABSTRACT
The management of COVID-19 has become more complex due to the expansion of available therapies. The presence of SARS-CoV-2 variants and mutations further complicate treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to characterise infections and guide treatment decisions.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Variants Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Topics: Variants Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid