Management of two circulations in a COVID-19 patient with secondary superinfection.
Physiol Rep
; 11(4): e15602, 2023 02.
Article
in English
| MEDLINE | ID: covidwho-2282398
ABSTRACT
Optimal oxygenation in the intensive care unit requires adequate pulmonary gas exchange, oxygen-carrying capacity in the form of hemoglobin, sufficient delivery of oxygenated hemoglobin to the tissue, and an appropriate tissue oxygen demand. In this Case Study in Physiology, we describe a patient with COVID-19 whose pulmonary gas exchange and oxygen delivery were severely compromised by COVID-19 pneumonia requiring extracorporeal membrane oxygenation (ECMO) support. His clinical course was complicated by a secondary superinfection with staphylococcus aureus and sepsis. This case study is provided with two goals in mind (1) We outline how basic physiology was used to address life-threatening consequences of a novel infection-COVID-19. (2) We describe a strategy of whole-body cooling to lower the cardiac output and oxygen consumption, use of the shunt equation to optimize flow to the ECMO circuit, and transfusion to improve oxygen-carrying capacity when ECMO alone failed to provide sufficient oxygenation.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Superinfection
/
COVID-19
Type of study:
Case report
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Physiol Rep
Year:
2023
Document Type:
Article
Affiliation country:
Phy2.15602
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