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Imaging Fibrosis.
Sviridenko, Anna; di Santo, Gianpaolo; Virgolini, Irene.
  • Sviridenko A; Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: anna.sviridenko@tirol-kliniken.at.
  • di Santo G; Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
  • Virgolini I; Department of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
PET Clin ; 18(3): 381-388, 2023 Jul.
Article in English | MEDLINE | ID: covidwho-2283142
ABSTRACT
Tissue injury in nonmalignant human disease can develop from either disproportionate inflammation or exaggerated fibrotic responses. The molecular and cellular fundamental of these 2 processes, their impact on disease prognosis and the treatment concept deviates fundamentally. Consequently, the synchronous assessment and quantification of these 2 processes in vivo is extremely desirable. Although noninvasive molecular techniques such as 18F-fluorodeoxyglucose PET offer insights into the degree of inflammatory activity, the assessment of the molecular dynamics of fibrosis remains challenging. The 68Ga-fibroblast activation protein inhibitor-46 may improve noninvasive clinical diagnostic performance in patients with both fibroinflammatory pathology and long-term CT-abnormalities after severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: PET Clin Year: 2023 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: PET Clin Year: 2023 Document Type: Article