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Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19.
Sykes, Robert; Morrow, Andrew J; McConnachie, Alex; Kamdar, Anna; Bagot, C; Bayes, Hannah; Blyth, Kevin G; Briscoe, Michael; Bulluck, Heeraj; Carrick, David; Church, Colin; Corcoran, David; Delles, C; Findlay, Iain; Gibson, Vivienne B; Gillespie, Lynsey; Grieve, Douglas; Barrientos, Pauline Hall; Ho, Antonia; Lang, N N; Lowe, David J; Lennie, Vera; MacFarlane, Peter; Mayne, Kaithlin J; Mark, Patrick; McIntosh, Alasdair; McGeoch, Ross; McGinley, Christopher; Mckee, Connor; Nordin, Sabrina; Payne, Alexander; Rankin, Alastair; Robertson, Keith E; Ryan, Nicola; Roditi, Giles H; Sattar, Naveed; Stobo, David B; Allwood-Spiers, Sarah; Touyz, Rhian; Veldtman, Gruschen; Weeden, Sarah; Watkins, Stuart; Welsh, Paul; Wereski, Ryan; Mangion, Kenneth; Berry, Colin.
  • Sykes R; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Morrow AJ; Cardiology, Golden Jubilee National Hospital West of Scotland Regional Heart and Lung Centre, Glasgow, UK.
  • McConnachie A; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Kamdar A; Cardiology, Queen Elizabeth University Hospital, Glasgow, UK.
  • Bagot C; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
  • Bayes H; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Blyth KG; Haematology, Glasgow Royal Infirmary, Glasgow, UK.
  • Briscoe M; Respiratory Medicine, Glasgow Royal Infirmary, Glasgow, UK.
  • Bulluck H; School of Cancer Sciences, University of Glasgow, Glasgow, UK.
  • Carrick D; Respiratory Medicine, Queen Elizabeth University Hospital, Glasgow, UK.
  • Church C; Cardiology, Queen Elizabeth University Hospital, Glasgow, UK.
  • Corcoran D; Cardiology, Leeds General Infirmary, Leeds, West Yorkshire, UK.
  • Delles C; Cardiology, University Hospital Hairmyres, East Kilbride, South Lanarkshire, UK.
  • Findlay I; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Gibson VB; Scottish Pulmonary Vascular Unit, Golden Jubilee Hospital, Clydebank, UK.
  • Gillespie L; Cardiology, Queen Elizabeth University Hospital, Glasgow, UK.
  • Grieve D; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Barrientos PH; Cardiology, Royal Alexandra Hospital, Paisley, Renfrewshire, UK.
  • Ho A; Haemostasis and Thrombosis, Glasgow Royal Infirmary, Glasgow, UK.
  • Lang NN; Project Management Unit, Glasgow Clinical Research Facility, Glasgow, UK.
  • Lowe DJ; Respiratory Medicine, Royal Alexandra Hospital, Paisley, Renfrewshire, UK.
  • Lennie V; Medical Physics, NHS Greater Glasgow and Clyde, Glasgow, Glasgow, UK.
  • MacFarlane P; MRC-University of Glasgow Centre for Virus Research, School of Infection and Immunity, University of Glasgow, Glasgow, UK.
  • Mayne KJ; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Mark P; Cardiology, Queen Elizabeth University Hospital, Glasgow, UK.
  • McIntosh A; Emergency Medicine, Queen Elizabeth University Hospital, Glasgow, UK.
  • McGeoch R; Cardiology, Aberdeen Royal Infirmary, Aberdeen, Aberdeen, UK.
  • McGinley C; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Mckee C; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Nordin S; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Payne A; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
  • Rankin A; Cardiology, University Hospital Hairmyres, East Kilbride, South Lanarkshire, UK.
  • Robertson KE; Cardiology, Queen Elizabeth University Hospital, Glasgow, UK.
  • Ryan N; Cardiology, Queen Elizabeth University Hospital, Glasgow, UK.
  • Roditi GH; Cardiology, Queen Elizabeth University Hospital, Glasgow, UK.
  • Sattar N; Cardiology, University Hospital Crosshouse, Kilmarnock, East Ayrshire, UK.
  • Stobo DB; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Allwood-Spiers S; Cardiology, Golden Jubilee National Hospital West of Scotland Regional Heart and Lung Centre, Glasgow, UK.
  • Touyz R; Cardiology, Aberdeen Royal Infirmary, Aberdeen, Aberdeen, UK.
  • Veldtman G; Radiology, NHS Greater Glasgow and Clyde, Glasgow, Glasgow, UK.
  • Weeden S; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Watkins S; Radiology, NHS Greater Glasgow and Clyde, Glasgow, Glasgow, UK.
  • Welsh P; Respiratory Medicine, Queen Elizabeth University Hospital, Glasgow, UK.
  • Wereski R; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
  • Mangion K; Cardiology, Golden Jubilee National Hospital West of Scotland Regional Heart and Lung Centre, Glasgow, UK.
  • Berry C; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
Open Heart ; 10(1)2023 02.
Article in English | MEDLINE | ID: covidwho-2283194
ABSTRACT

BACKGROUND:

We investigated the associations of healthcare worker status with multisystem illness trajectory in hospitalised post-COVID-19 individuals. METHODS AND

RESULTS:

One hundred and sixty-eight patients were evaluated 28-60 days after the last episode of hospital care. Thirty-six (21%) were healthcare workers. Compared with non-healthcare workers, healthcare workers were of similar age (51.3 (8.7) years vs 55.0 (12.4) years; p=0.09) more often women (26 (72%) vs 48 (38%); p<0.01) and had lower 10-year cardiovascular risk (%) (8.1 (7.9) vs 15.0 (11.5); p<0.01) and Coronavirus Clinical Characterisation Consortium in-hospital mortality risk (7.3 (10.2) vs 12.7 (9.8); p<0.01). Healthcare worker status associated with less acute inflammation (peak C reactive protein 48 mg/L (IQR 14-165) vs 112 mg/L (52-181)), milder illness reflected by WHO clinical severity score distribution (p=0.04) and shorter duration of admission (4 days (IQR 2-6) vs 6 days (3-12)).In adjusted multivariate logistic regression analysis, healthcare worker status associated with a binary classification (probable/very likely vs not present/unlikely) of adjudicated myocarditis (OR 2.99; 95% CI (1.01 to 8.89) by 28-60 days postdischarge).After a mean (SD, range) duration of follow-up after hospital discharge of 450 (88) days (range 290, 627 days), fewer healthcare workers died or were rehospitalised (1 (3%) vs 22 (17%); p=0.038) and secondary care referrals for post-COVID-19 syndrome were common (42%) and similar to non-healthcare workers (38%; p=0.934).

CONCLUSION:

Healthcare worker status was independently associated with the likelihood of adjudicated myocarditis, despite better antecedent health. Two in five healthcare workers had a secondary care referral for post-COVID-19 syndrome. TRIAL REGISTRATION NUMBER NCT04403607.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Myocarditis Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2023 Document Type: Article Affiliation country: Openhrt-2022-002192

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Myocarditis Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2023 Document Type: Article Affiliation country: Openhrt-2022-002192